V
Valeriia Haberland
Researcher at University of Bristol
Publications - 25
Citations - 4687
Valeriia Haberland is an academic researcher from University of Bristol. The author has contributed to research in topics: Resource (project management) & Grid. The author has an hindex of 8, co-authored 24 publications receiving 1709 citations. Previous affiliations of Valeriia Haberland include Medical Research Council & Goldsmiths, University of London.
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Journal ArticleDOI
The MR-Base platform supports systematic causal inference across the human phenome
Gibran Hemani,Jie Zheng,Benjamin Elsworth,Kaitlin H Wade,Valeriia Haberland,Denis Baird,Charles Laurin,Stephen Burgess,Jack Bowden,Ryan Langdon,Vanessa Y Tan,James Yarmolinsky,Hashem A Shihab,Nicholas J. Timpson,David M. Evans,David M. Evans,Caroline L Relton,Richard M. Martin,George Davey Smith,Tom R. Gaunt,Philip C Haycock +20 more
TL;DR: MR-Base is a platform that integrates a curated database of complete GWAS results (no restrictions according to statistical significance) with an application programming interface, web app and R packages that automate 2SMR, and includes several sensitivity analyses for assessing the impact of horizontal pleiotropy and other violations of assumptions.
Peer ReviewDOI
Author response: The MR-Base platform supports systematic causal inference across the human phenome
Gibran Hemani,Jie Zheng,Benjamin Elsworth,Kaitlin H Wade,Valeriia Haberland,Denis Baird,Charles Laurin,Stephen Burgess,Jack Bowden,Ryan Langdon,Vanessa Y Tan,James Yarmolinsky,Hashem A Shihab,Nicholas J. Timpson,David M. Evans,David M. Evans,Caroline L Relton,Richard M. Martin,George Davey Smith,Tom R. Gaunt,Philip C Haycock +20 more
Posted ContentDOI
The MRC IEU OpenGWAS data infrastructure
Ben Elsworth,Matthew Lyon,Matthew Lyon,Tessa Alexander,Yi Liu,Peter Matthews,Jon Hallett,Phil Bates,Phil Bates,Tom Palmer,Valeriia Haberland,George Davey Smith,Jie Zheng,Philip C Haycock,Tom R. Gaunt,Tom R. Gaunt,Gibran Hemani +16 more
TL;DR: The OpenGWAS database is presented, an open source, open access, scalable and high-performance cloud-based data infrastructure that imports and publishes complete GWAS summary datasets and metadata for the scientific community.
Journal ArticleDOI
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
Ioanna Tachmazidou,Konstantinos Hatzikotoulas,Lorraine Southam,Lorraine Southam,Jorge Esparza-Gordillo,Valeriia Haberland,Jie Zheng,Toby Johnson,Mine Koprulu,Mine Koprulu,Eleni Zengini,Julia Steinberg,Julia Steinberg,Jeremy Mark Wilkinson,Sahir Bhatnagar,Joshua D. Hoffman,Natalie Buchan,Daniel Suveges,Laura M Yerges Armstrong,George Davey Smith,Tom R. Gaunt,Robert A. Scott,Linda McCarthy,Eleftheria Zeggini +23 more
TL;DR: Integrated eQTL colocalization, fine-mapping, and rare-disease data identify putative effector genes for osteoarthritis, including TGFB1 (transforming growth factor beta 1), FGF18 (fibroblast growth factor 18), CTSK (cathepsin K), and IL11 (interleukin 11).
Journal ArticleDOI
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
Jie Zheng,Valeriia Haberland,Denis Baird,Venexia M Walker,Philip C Haycock,Mark R. Hurle,Alex Gutteridge,Pau Erola,Yi Liu,Shan Luo,Shan Luo,Jamie Robinson,Tom G. Richardson,James R Staley,James R Staley,Benjamin Elsworth,Stephen Burgess,Benjamin B. Sun,John Danesh,Heiko Runz,Joseph C. Maranville,Hannah M. Martin,James Yarmolinsky,Charles Laurin,Michael V. Holmes,Jimmy Z. Liu,Karol Estrada,Rita Santos,Linda McCarthy,Dawn M. Waterworth,Matthew R. Nelson,George Davey Smith,Adam S. Butterworth,Gibran Hemani,Robert A. Scott,Tom R. Gaunt +35 more
TL;DR: Evaluation of data from historic drug development programs showed that target-indication pairs with MR and colocalization support were more likely to be approved, evidencing the value of this approach in identifying and prioritizing potential therapeutic targets.