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Heiko Runz
Researcher at Biogen Idec
Publications - 103
Citations - 7501
Heiko Runz is an academic researcher from Biogen Idec. The author has contributed to research in topics: Genome-wide association study & Biology. The author has an hindex of 35, co-authored 82 publications receiving 5259 citations. Previous affiliations of Heiko Runz include Molecular Medicine Partnership Unit & European Bioinformatics Institute.
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Journal ArticleDOI
Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo
Klaus Fassbender,Mikael Simons,C. Bergmann,Mark Stroick,Dieter Lütjohann,Patrick Keller,Heiko Runz,Sandra Kühl,Thomas Bertsch,K. von Bergmann,M. Hennerici,Konrad Beyreuther,Tobias Hartmann +12 more
TL;DR: It is demonstrated that the widely used cholesterol-lowering drugs simvastatin and lovastatin reduce intracellular and extracellular levels of Aβ42 and Aβ40 peptides in primary cultures of hippocampal neurons and mixed cortical neurons, suggesting that lipids are playing an important role in the development of Alzheimer's disease.
Journal ArticleDOI
Genomic atlas of the human plasma proteome.
Benjamin B. Sun,Joseph C. Maranville,James E. Peters,James E. Peters,David Stacey,James R Staley,James A. Blackshaw,Stephen Burgess,Tao Jiang,Ellie Paige,Ellie Paige,Praveen Surendran,Clare Oliver-Williams,Mihir A Kamat,Bram P. Prins,Sheri K. Wilcox,Erik S Zimmerman,An Chi,Narinder Bansal,Narinder Bansal,Sarah L. Spain,Angela M. Wood,Nicholas W. Morrell,Nicholas W. Morrell,John Bradley,Nebojsa Janjic,David J. Roberts,David J. Roberts,Willem H. Ouwehand,John A. Todd,Nicole Soranzo,Karsten Suhre,Dirk S. Paul,Caroline S. Fox,Robert M. Plenge,John Danesh,John Danesh,Heiko Runz,Adam S. Butterworth +38 more
TL;DR: The genetic architecture of the human plasma proteome in healthy blood donors from the INTERVAL study is characterized, and it is shown that protein quantitative trait loci overlap with gene expression quantitative traits, as well as with disease-associated loci, and evidence that protein biomarkers have causal roles in disease is found.
Journal ArticleDOI
Genome-Wide Association Analysis in Primary Sclerosing Cholangitis
Tom H. Karlsen,Andre Franke,Espen Melum,Arthur Kaser,Johannes R. Hov,Tobias Balschun,Benedicte A. Lie,Annika Bergquist,Christoph Schramm,Tobias J. Weismüller,Daniel Gotthardt,Christian Rust,Eva E. R. Philipp,Teresa Fritz,Liesbet Henckaerts,Rinse K. Weersma,Pieter C. F. Stokkers,Cyriel Y. Ponsioen,Cisca Wijmenga,Martina Sterneck,Michael Nothnagel,Jochen Hampe,Andreas Teufel,Heiko Runz,Philip Rosenstiel,Adolf Stiehl,Severine Vermeire,Ulrich Beuers,Michael P. Manns,Erik Schrumpf,Kirsten Muri Boberg,Stefan Schreiber +31 more
TL;DR: Strong HLA associations and a subset of genes involved in bile homeostasis and other inflammatory conditions constitute key components of the genetic architecture of PSC.
Journal ArticleDOI
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Nick Shrine,Anna L. Guyatt,A. Mesut Erzurumluoglu,Victoria E. Jackson,Victoria E. Jackson,Victoria E. Jackson,Brian D. Hobbs,Carl A. Melbourne,Chiara Batini,Katherine A. Fawcett,Kijoung Song,Phuwanat Sakornsakolpat,Phuwanat Sakornsakolpat,Xingnan Li,Ruth Boxall,Nicola F. Reeve,Ma'en Obeidat,Jing Hua Zhao,Matthias Wielscher,Stefan Weiss,Katherine A. Kentistou,James P. Cook,Benjamin B. Sun,Jian Zhou,Jennie Hui,Stefan Karrasch,Medea Imboden,Sarah E. Harris,Jonathan Marten,Stefan Enroth,Shona M. Kerr,Ida Surakka,Vitart,Terho Lehtimäki,Richard J. Allen,Per Bakke,Terri H. Beaty,Eugene R. Bleecker,Yohan Bossé,Corry-Anke Brandsma,Zhengming Chen,James D. Crapo,John Danesh,Dawn L. DeMeo,Frank Dudbridge,Ralf Ewert,Christian Gieger,Amund Gulsvik,Anna Hansell,Ke Hao,Joshua D. Hoffman,John E. Hokanson,Georg Homuth,Peter K. Joshi,Philippe Joubert,Claudia Langenberg,Liming Li,Kuang Lin,Lars Lind,Nicholas Locantore,Jian'an Luan,Anubha Mahajan,Joseph C. Maranville,Alison Catherine Murray,David C. Nickle,Richard Packer,Margaret M. Parker,Megan L. Paynton,David J. Porteous,Dmitry Prokopenko,Dandi Qiao,Rajesh Rawal,Heiko Runz,Ian Sayers,Don D. Sin,Blair H. Smith,María Soler Artigas,David Sparrow,Ruth Tal-Singer,Timmers Prhj,van den Berge M,John C. Whittaker,Prescott G. Woodruff,Laura M Yerges Armstrong,Olga G. Troyanskaya,Olli T. Raitakari,Mika Kähönen,Ozren Polasek,Ozren Polasek,Ulf Gyllensten,Igor Rudan,Ian J. Deary,Nicole Probst-Hensch,Nicole Probst-Hensch,Holger Schulz,Alan James,Alan James,James F. Wilson,Beate Stubbe,Eleftheria Zeggini,Marjo-Riitta Järvelin,Nicholas J. Wareham,Edwin K. Silverman,Caroline Hayward,Andrew P. Morris,Andrew P. Morris,Adam S. Butterworth,Robert A. Scott,Robin G Walters,Deborah A. Meyers,Michael H. Cho,David P. Strachan,Ian P. Hall,Tobin,Louise V. Wain,Louise V. Wain +115 more
TL;DR: In this paper, a genome-wide association study in 400,102 individuals of European ancestry was conducted to define 279 lung function signals, 139 of which are new and the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups.
Journal ArticleDOI
Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
Timothy M. Miller,Merit Cudkowicz,Pamela J. Shaw,Peter M. Andersen,Nazem Atassi,Robert C. Bucelli,Angela Genge,Jonathan Glass,Shafeeq Ladha,Albert L. Ludolph,Nicholas J. Maragakis,Christopher J McDermott,Alan Pestronk,John Ravits,François Salachas,Randall G. Trudell,Philip Van Damme,Lorne Zinman,C. Frank Bennett,Roger Lane,Alfred Sandrock,Heiko Runz,Danielle Graham,Hani Houshyar,Alexander McCampbell,Ivan Nestorov,Ih Chang,Manjit McNeill,Laura Fanning,Stephanie Fradette,Toby A. Ferguson +30 more
TL;DR: In adults with ALS due to SOD1 mutations, CSF S OD1 concentrations decreased at the highest concentration of tofersen administered intrathecally over a period of 12 weeks.