Vanessa Tran

TL;DR: New developments in sophisticated genome analysis techniques and advances in knowledge of the virulence mechanisms of Mycobacterium tuberculosis have provided greater insights into the attenuation and evolution of BCG, with extremely important implications for national immunization programmes and the development of future vaccines.

TL;DR: This study isolated seven mutants of Mycobacterium marinum deficient in PDIMs and/or PGLs in which multiple genes of the PDIM/PGL biosynthetic locus were disrupted by transposon insertion and found that these strains were hypersensitive to antibiotics and exhibited increased cell wall permeability.

TL;DR: It is demonstrated that major virulence factors are different among BCG strains, which provide molecular mechanisms for important vaccine phenotypes including adverse effect profile, tuberculin reactivity and protective efficacy.

TL;DR: A role for dysregulation of the Ang–Tie-2 axis in the pathogenesis of cerebral malaria is defined and evaluation of Ang-1 and Tie-2–based interventions as potential adjunctive therapies for treating severe malaria is supported.

TL;DR: In this paper, the authors evaluated the SARS-CoV-2 antibody response in patients undergoing chronic hemodialysis following 1 vs 2 doses of BNT162b2 COVID-19 vaccination compared with health care workers serving as controls and convalescent serum.