Q
Qian Gao
Researcher at Fudan University
Publications - 137
Citations - 6109
Qian Gao is an academic researcher from Fudan University. The author has contributed to research in topics: Tuberculosis & Mycobacterium tuberculosis. The author has an hindex of 39, co-authored 114 publications receiving 4960 citations. Previous affiliations of Qian Gao include Fudan University Shanghai Medical College.
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Journal ArticleDOI
Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans
Iñaki Comas,Mireia Coscolla,Mireia Coscolla,Tao Luo,Sonia Borrell,Sonia Borrell,Kathryn E. Holt,Midori Kato-Maeda,Julian Parkhill,Bijaya Malla,Bijaya Malla,Stefan Berg,Guy E. Thwaites,Dorothy Yeboah-Manu,Graham H. Bothamley,Jian Mei,Lan-Hai Wei,Stephen D. Bentley,Simon R. Harris,Stefan Niemann,Roland Diel,Abraham Aseffa,Qian Gao,Douglas B. Young,Douglas B. Young,Sebastien Gagneux,Sebastien Gagneux +26 more
TL;DR: Coalescent analyses indicate that MTBC emerged about 70,000 years ago, accompanied migrations of anatomically modern humans out of Africa and expanded as a consequence of increases in human population density during the Neolithic period, consistent with MTBC displaying characteristics indicative of adaptation to both low and high host densities.
Journal ArticleDOI
Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing.
Caroline Allix-Béguec,Irena Arandjelovic,Lijun Bi,Patrick Beckert,Maryline Bonnet,Phelim Bradley,Andrea M. Cabibbe,Irving Cancino-Muñoz,Mark J. Caulfield,Angkana Chaiprasert,Daniela Maria Cirillo,David A. Clifton,Iñaki Comas,Derrick W. Crook,Maria Rosaria De Filippo,Han de Neeling,Roland Diel,Francis Drobniewski,Kiatichai Faksri,Maha R. Farhat,Joy Fleming,Philip W. Fowler,Tom Fowler,Qian Gao,Jennifer L. Gardy,Deborah Gascoyne-Binzi,Ana-Luiza Gibertoni-Cruz,Ana Gil-Brusola,Tanya Golubchik,Ximena Gonzalo,Louis Grandjean,Guangxue He,Jennifer L. Guthrie,Sarah Hoosdally,Martin Hunt,Zamin Iqbal,Nazir Ahmed Ismail,James C. Johnston,Faisal Masood Khanzada,Chiea Chuen Khor,Thomas Kohl,Clare Kong,Samuel Lipworth,Qingyun Liu,Gugu Maphalala,Elena Martinez,Vanessa Mathys,Matthias Merker,Paolo Miotto,Nerges Mistry,David Moore,Megan Murray,Stefan Niemann,Shaheed V. Omar,Rick T-H Ong,Tim E. A. Peto,James E. Posey,Therdsak Prammananan,Alexander S. Pym,Camilla Rodrigues,Mabel Rodrigues,Timothy C. Rodwell,Gian Maria Rossolini,Elisabeth Sánchez Padilla,Marco Schito,Xin Shen,Jay Shendure,Vitali Sintchenko,Alexander Sloutsky,E. Grace Smith,Matthew W. Snyder,Karine Soetaert,Angela M. Starks,Philip Supply,Prapat Suriyapol,Sabira Tahseen,Patrick Tang,Yik Ying Teo,Thuong N T Thuong,Guy E. Thwaites,Enrico Tortoli,Dick van Soolingen,A. Sarah Walker,Timothy M Walker,Mark H. Wilcox,Daniel J. Wilson,David H. Wyllie,Yang Yang,Hongtai Zhang,Yanlin Zhao,Baoli Zhu +90 more
TL;DR: Genotypic predictions of the susceptibility of M. tuberculosis to first‐line drugs were found to be correlated with phenotypic susceptibility to these drugs.
Journal ArticleDOI
Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human Macrophages
Hélène Botella,Hélène Botella,Pascale Peyron,Pascale Peyron,Florence Levillain,Florence Levillain,Renaud Poincloux,Renaud Poincloux,Yannick Poquet,Yannick Poquet,Irène Brandli,Irène Brandli,Irène Brandli,Chuan Wang,Chuan Wang,Chuan Wang,Ludovic Tailleux,Sylvain Tilleul,Guillaume M. Charrière,Guillaume M. Charrière,Simon J. Waddell,Maria Foti,Geanncarlo Lugo-Villarino,Geanncarlo Lugo-Villarino,Qian Gao,Isabelle Maridonneau-Parini,Isabelle Maridonneau-Parini,Philip D. Butcher,Paola Ricciardi Castagnoli,Brigitte Gicquel,Chantal de Chastellier,Chantal de Chastellier,Chantal de Chastellier,Olivier Neyrolles,Olivier Neyrolles +34 more
TL;DR: The use of P1-type ATPases represents a M. tuberculosis strategy to neutralize the toxic effects of zinc in macrophages, suggesting that heavy metal toxicity and its counteraction might represent yet another chapter in the host-microbe arms race.
Journal ArticleDOI
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.
David Stucki,David Stucki,Daniela Brites,Daniela Brites,Leïla Jeljeli,Mireia Coscolla,Mireia Coscolla,Qingyun Liu,Andrej Trauner,Andrej Trauner,Lukas Fenner,Lukas Fenner,Lukas Fenner,Liliana K. Rutaihwa,Liliana K. Rutaihwa,Sonia Borrell,Sonia Borrell,Tao Luo,Qian Gao,Midori Kato-Maeda,Marie Ballif,Marie Ballif,Marie Ballif,Matthias Egger,Rita Macedo,Helmi Mardassi,Milagros Moreno,Griselda Tudo Vilanova,Janet A. M. Fyfe,Maria Globan,Jackson Thomas,Frances B. Jamieson,Jennifer L. Guthrie,Adwoa Asante-Poku,Dorothy Yeboah-Manu,Eddie M. Wampande,Willy Ssengooba,Willy Ssengooba,Moses Joloba,W. Henry Boom,Indira Basu,James E. Bower,Margarida Saraiva,Sidra Ezidio Gonçalves Vasconcellos,Philip Noel Suffys,Anastasia Koch,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Linda Gail-Bekker,Bijaya Malla,Bijaya Malla,Serej D. Ley,Serej D. Ley,Serej D. Ley,Hans-Peter Beck,Hans-Peter Beck,Bouke C. de Jong,Kadri Toit,Elisabeth Sanchez-Padilla,Maryline Bonnet,Ana Gil-Brusola,Matthias Frank,Véronique Penlap Beng,Kathleen D. Eisenach,Issam Alani,Perpetual Wangui Ndung'u,Gunturu Revathi,Florian Gehre,Florian Gehre,Suriya Akter,Francine Ntoumi,Lynsey Stewart-Isherwood,Nyanda E. Ntinginya,Andrea Rachow,Michael Hoelscher,Daniela Maria Cirillo,Girts Skenders,Sven Hoffner,Daiva Bakonyte,Petras Stakenas,Roland Diel,Valeriu Crudu,Olga Domnica Moldovan,Sahal Al-Hajoj,Larissa Otero,Francesca Barletta,E. Jane Carter,E. Jane Carter,Lameck Diero,Philip Supply,Iñaki Comas,Stefan Niemann,Sebastien Gagneux,Sebastien Gagneux +94 more
TL;DR: It is shown that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists, and further support a European origin for the most common generalist sublineage.
Journal ArticleDOI
Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues.
Conor J. Meehan,Galo A. Goig,Thomas Kohl,Lennert Verboven,Anzaan Dippenaar,Matthew Ezewudo,Maha R. Farhat,Jennifer L. Guthrie,Kris Laukens,Paolo Miotto,Boatema Ofori-Anyinam,Viola Dreyer,Philip Supply,Anita Suresh,Christian Utpatel,Dick van Soolingen,Yang Zhou,Philip Ashton,Daniela Brites,Daniela Brites,Andrea M. Cabibbe,Bouke C. de Jong,Margaretha de Vos,Fabrizio Menardo,Fabrizio Menardo,Sebastien Gagneux,Sebastien Gagneux,Qian Gao,Tim H. Heupink,Qingyun Liu,Chloé Loiseau,Chloé Loiseau,Leen Rigouts,Timothy C. Rodwell,Elisa Tagliani,Timothy M Walker,Robin M. Warren,Yanlin Zhao,Matteo Zignol,Marco Schito,Jennifer L. Gardy,Daniela Maria Cirillo,Stefan Niemann,Iñaki Comas,Annelies Van Rie +44 more
TL;DR: The current landscape of WGS pipelines and applications, and best practices for M.tuberculosis WGS, are outlined, including standards for bioinformatics pipelines, curated repositories of resistance-causing variants, phylogenetic analyses, quality control and standardized reporting.