V
Vanina Dengler
Researcher at Harvard University
Publications - 9
Citations - 491
Vanina Dengler is an academic researcher from Harvard University. The author has contributed to research in topics: Teichoic acid & Cell wall. The author has an hindex of 7, co-authored 9 publications receiving 423 citations. Previous affiliations of Vanina Dengler include ETH Zurich & University of Zurich.
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Journal ArticleDOI
An Electrostatic Net Model for the Role of Extracellular DNA in Biofilm Formation by Staphylococcus aureus
TL;DR: It is suggested that eDNA acts as an electrostatic net, interconnecting cells surrounded by positively charged matrix proteins at a low pH, that tethers cells together via the proteinaceous layer of the biofilm matrix.
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Staphylococcus aureus Mutants Lacking the LytR-CpsA-Psr Family of Enzymes Release Cell Wall Teichoic Acids into the Extracellular Medium
Yvonne G. Y. Chan,Matthew B. Frankel,Vanina Dengler,Olaf Schneewind,Olaf Schneewind,Dominique Missiakas,Dominique Missiakas +6 more
TL;DR: A model whereby the S. aureus Δlcp mutant, defective in tethering WTA to the cell wall, cleaves WTA synthesis intermediates, releasing ribitol phosphate into the medium and recycling bactoprenol for peptidoglycan synthesis is proposed.
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Induction kinetics of the Staphylococcus aureus cell wall stress stimulon in response to different cell wall active antibiotics.
Vanina Dengler,Patricia Stutzmann Meier,Ronald Heusser,Brigitte Berger-Bächi,Nadine McCallum +4 more
TL;DR: Differences observed in optimal induction conditions for specific antibiotics should be determined and taken into account when designing and interpreting CWSS induction studies.
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Mutation in the C-Di-AMP Cyclase dacA Affects Fitness and Resistance of Methicillin Resistant Staphylococcus aureus
Vanina Dengler,Nadine McCallum,Nadine McCallum,Patrick Kiefer,Philipp Christen,Andrea Patrignani,Julia A. Vorholt,Brigitte Berger-Bächi,Maria M. Senn +8 more
TL;DR: Results indicate that c-di-AMP affects cell envelope-related signalling in S. aureus and could be a mechanism by which MRSA strains can increase their fitness levels by reducing their methicillin resistance levels.
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Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response
Vanina Dengler,Patricia Stutzmann Meier,Ronald Heusser,Peter Kupferschmied,Judit Fazekas,Sarah Friebe,Sibylle Burger Staufer,Paul Majcherczyk,Philippe Moreillon,Brigitte Berger-Bächi,Nadine McCallum,Nadine McCallum +11 more
TL;DR: Intrinsic activation of the CWSS upon LCP deletion and the fact that LCP proteins were essential for WTA-loading of the cell wall, highlight their important role(s) in S. aureus cell envelope biogenesis.