V
Varsha M. Patel
Researcher at King's College London
Publications - 4
Citations - 393
Varsha M. Patel is an academic researcher from King's College London. The author has contributed to research in topics: Gene & Gene silencing. The author has an hindex of 4, co-authored 4 publications receiving 308 citations.
Papers
More filters
Journal ArticleDOI
AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking
Niovi Setta-Kaffetzi,Michael A. Simpson,Alexander A. Navarini,Varsha M. Patel,Hui-Chun Lu,Michael H. Allen,Michael Duckworth,Hervé Bachelez,A. David Burden,Siew Eng Choon,Christopher E.M. Griffiths,Brian Kirby,Antonios G.A. Kolios,Marieke M B Seyger,Christa Prins,Asma Smahi,Richard C. Trembath,Richard C. Trembath,Franca Fraternali,Catherine H. Smith,Jonathan Barker,Francesca Capon +21 more
TL;DR: It is found that AP1S3 silencing disrupted the endosomal translocation of the innate pattern-recognition receptor TLR-3 (Toll-like receptor 3) and resulted in a marked inhibition of downstream signaling.
Journal ArticleDOI
Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes.
Niovi Setta-Kaffetzi,Alexander A. Navarini,Varsha M. Patel,Venu Pullabhatla,Andrew Pink,Siew Eng Choon,M Allen,A. David Burden,Christopher E.M. Griffiths,Marieke M B Seyger,Brian Kirby,Richard C. Trembath,Richard C. Trembath,Michael A. Simpson,Catherine H. Smith,Francesca Capon,Jonathan Barker +16 more
Journal ArticleDOI
Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome.
Wesley J. Woollard,Venu Pullabhatla,Anna Lorenc,Varsha M. Patel,Rosie M. Butler,Anthony Bayega,Nelema Begum,Farrah S. Bakr,Kiran Dedhia,Joshua Fisher,Silvia Aguilar-Duran,Charlotte E. Flanagan,Aria A. Ghasemi,Ricarda M. Hoffmann,Nubia Castillo-Mosquera,Elisabeth A. Nuttall,Arisa Paul,Ceri A. Roberts,Emmanouil G Solomonidis,Rebecca Tarrant,Antoinette Yoxall,Carl Z. Beyers,Silvia Ferreira,Isabella Tosi,Michael A. Simpson,Emanuele de Rinaldis,Tracey J. Mitchell,Sean Whittaker +27 more
TL;DR: This study provides the basis for a detailed functional analysis of malignant transformation of mature T cells and improved patient stratification and treatment in SS.
Journal ArticleDOI
Frequent and Persistent PLCG1 Mutations in Sézary Cells Directly Enhance PLCγ1 Activity and Stimulate NFκB, AP-1, and NFAT Signaling.
Varsha M. Patel,Charlotte E. Flanagan,Marta Martins,Christine L. Jones,Rosie M. Butler,Wesley J. Woollard,Farrah S. Bakr,Antoinette Yoxall,Nelema Begum,Matilda Katan,Sean Whittaker,Tracey J. Mitchell +11 more
TL;DR: In this paper, the authors investigate nine PLCG1 mutations (p.R48W, p.R1158H, pE1163K, pD1165H, and the in-frame indel p.VYEEDM1161V) identified in Sezary Syndrome, the leukemic variant of CTCL.