Vassilios Beglopoulos

TL;DR: It is demonstrated that conditional double knockout mice lacking both presenilins in the postnatal forebrain exhibit impairments in hippocampal memory and synaptic plasticity and these deficits are associated with specific reductions in NMDA receptor-mediated responses and synaptic levels of NMDA receptors and alphaCaMKII.

TL;DR: Results indicate a selective role for presenilins in the activity-dependent regulation of neurotransmitter release and long-term potentiation induction by modulation of intracellular Ca2+ release in presynaptic terminals, and suggest that Presynaptic dysfunction might be an early pathogenic event leading to dementia and neurodegeneration in Alzheimer’s disease.

TL;DR: The results indicate that the memory impairment and neurodegeneration in PS cDKO mice are not caused by Aβ accumulation and that loss of PS function leads to differential up-regulation of inflammatory markers in the cerebral cortex.

TL;DR: Support is provided for a role of Notch1 in neuronal subtype specification in the ventral spinal cord using conditional knockout mice lacking notch1 specifically in neural progenitor cells.

TL;DR: The data suggest an important role for Nxph3 as a locally and temporally regulated neuropeptide-like molecule, presumably acting in a complex with α-neurexins in select neuronal circuits.