V
Venkatesh Krishnan
Researcher at Eli Lilly and Company
Publications - 43
Citations - 2869
Venkatesh Krishnan is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Estrogen receptor & Agonist. The author has an hindex of 22, co-authored 43 publications receiving 2155 citations.
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Journal ArticleDOI
Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction
William P. Cawthorn,Erica L. Scheller,Brian S. Learman,Sebastian D. Parlee,Becky R. Simon,Hiroyuki Mori,Xiaomin Ning,Adam J. Bree,Benjamin Schell,David T. Broome,Sandra S. Soliman,Jenifer L. DelProposto,Carey N. Lumeng,Aditi Mitra,Sandeep V. Pandit,Katherine A. Gallagher,Joshua D. Miller,Venkatesh Krishnan,Susanta K. Hui,Miriam A. Bredella,Pouneh K. Fazeli,Anne Klibanski,Mark C. Horowitz,Clifford J. Rosen,Ormond A. MacDougald +24 more
TL;DR: It is revealed that both MAT and serum adiponectin increase during cancer therapy in humans, and these observations identify MAT as an endocrine organ that contributes significantly to increased serum adip onectin during CR and perhaps in other adverse states.
Journal ArticleDOI
Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial.
Vincent C. Marconi,Vincent C. Marconi,Athimalaipet V Ramanan,Stephanie de Bono,Cynthia E. Kartman,Venkatesh Krishnan,Ran Liao,Maria Lucia B. Piruzeli,Jason D Goldman,Jorge Alatorre-Alexander,Rita de Cassia Pellegrini,Vicente Estrada,Mousumi Som,Anabela Cardoso,Sujatro Chakladar,Brenda J. Crowe,Paulo Reis,Xin Zhang,David H. Adams,E. Wesley Ely +19 more
TL;DR: Baricitinib is an oral selective Janus kinase 1/2 inhibitor with known anti-inflammatory properties as discussed by the authors, which has been shown to reduce mortality in hospitalised adults with COVID-19.
Journal ArticleDOI
Wnt10b Increases Postnatal Bone Formation by Enhancing Osteoblast Differentiation
Christina N. Bennett,Hongjiao Ouyang,Yanfei L. Ma,Qingqiang Zeng,Isabelle Gerin,Kyle M. Sousa,Timothy F. Lane,Venkatesh Krishnan,Kurt D. Hankenson,Ormond A. MacDougald +9 more
TL;DR: In this article, Wnt signaling regulates many aspects of development including postnatal accrual of bone, including bone formation and bone formation rate, by stimulating osteoblastogenesis.
Journal ArticleDOI
Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.
Justin Stebbing,Venkatesh Krishnan,Stephanie de Bono,Silvia Ottaviani,Giacomo Casalini,Peter J. Richardson,Vanessa Monteil,Volker M. Lauschke,Ali Mirazimi,Sonia Youhanna,Yee-Joo Tan,Yee-Joo Tan,Fausto Baldanti,Antonella Sarasini,Jorge A. Ross Terres,Brian J. Nickoloff,Richard E. Higgs,Guilherme Rocha,Nicole L. Byers,Douglas E Schlichting,Ajay Nirula,Anabela Cardoso,Mario Corbellino +22 more
TL;DR: In a case series of patients with bilateral COVID‐19 pneumonia, baricitinib treatment was associated with clinical and radiologic recovery, a rapid decline in SARS‐CoV‐2 viral load, inflammatory markers, and IL‐6 levels, and these data support further evaluation of the anti‐cytokine and anti‐viral activity of baricit inib and support its assessment in randomized trials in hospitalized CO VID‐19 patients.
Journal ArticleDOI
Osteoblast Apoptosis and Bone Turnover
Janet M. Hock,Venkatesh Krishnan,Jude E. Onyia,Jude E. Onyia,Joseph Bidwell,J. Milas,D. Stanislaus +6 more
TL;DR: The paradoxical effects of parathyroid hormone (PTH) on osteoblast apoptosis in vivo are considered in the perspective of a recent hypothesis speculating that this may be a key mechanism to explain the anabolic effects of the hormone.