V
Venu M. Nemani
Researcher at University of California, San Francisco
Publications - 18
Citations - 2667
Venu M. Nemani is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Synaptic vesicle. The author has an hindex of 9, co-authored 11 publications receiving 2409 citations.
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Journal ArticleDOI
Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
Venu M. Nemani,Wei Lu,Victoria Berge,Ken Nakamura,Bibiana Onoa,Michael K. Lee,Farrukh A. Chaudhry,Roger A. Nicoll,Robert H. Edwards +8 more
TL;DR: It is found that the modest overexpression of alpha-synuclein, in the range predicted for gene multiplication and in the absence of overt toxicity, markedly inhibits neurotransmitter release.
Journal ArticleDOI
Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
Ken Nakamura,Venu M. Nemani,Farnaz Azarbal,Gaia Skibinski,Jon M. Levy,Kiyoshi Egami,Larissa A. Munishkina,Jue Zhang,Brooke M. Gardner,Junko Wakabayashi,Hiromi Sesaki,Yifan Cheng,Steven Finkbeiner,Robert L. Nussbaum,Eliezer Masliah,Robert H. Edwards +15 more
TL;DR: It is shown that the expression of α-synuclein in mammalian cells, including neurons in vitro and in vivo, causes the fragmentation of mitochondria.
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α-Synuclein Overexpression in PC12 and Chromaffin Cells Impairs Catecholamine Release by Interfering with a Late Step in Exocytosis
Kristin E. Larsen,Yvonne Schmitz,Matthew D. Troyer,Eugene V. Mosharov,Paula Dietrich,Abrar Z. Quazi,Magali Savalle,Venu M. Nemani,Farrukh A. Chaudhry,Robert H. Edwards,Leonidas Stefanis,Leonidas Stefanis,David Sulzer +12 more
TL;DR: Overexpression of wild-type or A30P mutant α-syn in PC12 cell lines inhibited evoked catecholamine release without altering calcium threshold or cooperativity of release, and inhibits a vesicle “priming” step, after secretory vesicular trafficking to “docked” sites but before calcium-dependent vesicles membrane fusion.
Journal ArticleDOI
Neural activity controls the synaptic accumulation of alpha-synuclein.
Doris L. Fortin,Venu M. Nemani,Susan M. Voglmaier,Malcolm D. Anthony,Timothy A. Ryan,Robert H. Edwards +5 more
TL;DR: It is found that α-synuclein disperses from the nerve terminal in response to neural activity, and unlike other synaptic vesicle proteins, α- synuclein dissociates from the synaptic vedic membrane after fusion.
Journal ArticleDOI
Optical Reporters for the Conformation of α-Synuclein Reveal a Specific Interaction with Mitochondria
Ken Nakamura,Venu M. Nemani,Erika K. Wallender,Katrin Kaehlcke,Melanie Ott,Robert H. Edwards +5 more
TL;DR: It is found that the conformation of α-synuclein responds selectively to mitochondria, indicating a direct link between α- synuclein and an organelle strongly implicated in the pathogenesis of PD.