G
Gaia Skibinski
Researcher at University of California, San Francisco
Publications - 25
Citations - 3232
Gaia Skibinski is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Neurodegeneration & Frontotemporal dementia. The author has an hindex of 14, co-authored 22 publications receiving 2840 citations. Previous affiliations of Gaia Skibinski include Gladstone Institutes & University College London.
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Journal ArticleDOI
Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia
Gaia Skibinski,Nicholas Parkinson,Jeremy M Brown,Lisa Chakrabarti,Lisa Chakrabarti,Sarah L Lloyd,Holger Hummerich,Jørgen E. Nielsen,Jørgen E. Nielsen,John R. Hodges,Maria Grazia Spillantini,Tove Thusgaard,Sebastian Brandner,Arne Brun,Martin N. Rossor,Anders Gade,Anders Gade,Peter Johannsen,Sven Asger Sørensen,Susanne Gydesen,Elizabeth M. C. Fisher,John Collinge +21 more
TL;DR: A mutation in CHMP2B, encoding a component of the endosomal ESCRTIII complex, is identified and it is shown that it results in aberrant mRNA splicing in tissue samples from affected members of this family.
Journal ArticleDOI
Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
Ken Nakamura,Venu M. Nemani,Farnaz Azarbal,Gaia Skibinski,Jon M. Levy,Kiyoshi Egami,Larissa A. Munishkina,Jue Zhang,Brooke M. Gardner,Junko Wakabayashi,Hiromi Sesaki,Yifan Cheng,Steven Finkbeiner,Robert L. Nussbaum,Eliezer Masliah,Robert H. Edwards +15 more
TL;DR: It is shown that the expression of α-synuclein in mammalian cells, including neurons in vitro and in vivo, causes the fragmentation of mitochondria.
Journal ArticleDOI
In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images
Eric Christiansen,Samuel Yang,D. Michael Ando,Ashkan Javaherian,Gaia Skibinski,Scott Lipnick,Elliot Mount,Alison O’Neil,Kevan Shah,Alicia K. Lee,Piyush Goyal,William Fedus,William Fedus,Ryan Poplin,Andre Esteva,Andre Esteva,Marc Berndl,Lee L. Rubin,Philip C. Nelson,Steven Finkbeiner,Steven Finkbeiner +20 more
TL;DR: It is shown that a computational machine-learning approach, which is called "in silico labeling" (ISL), reliably predicts some fluorescent labels from transmitted-light images of unlabeled fixed or live biological samples.
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Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
Sami J. Barmada,Gaia Skibinski,Erica Korb,Elizabeth J. Rao,Jane Y. Wu,Steven Finkbeiner,Steven Finkbeiner +6 more
TL;DR: In this article, a model of TDP-43 proteinopathies was established by expressing fluorescently tagged wild-type and mutant TDP43 in primary rat cortical neurons, and mutant specific toxicity was associated with increased cytoplasmic mislocalization of the protein.
Journal ArticleDOI
ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)
Nicholas Parkinson,Paul G. Ince,M. O. Smith,Robin Highley,Gaia Skibinski,Peter M Andersen,Karen E. Morrison,Hardev S. Pall,Orla Hardiman,John Collinge,Pamela J. Shaw,Elizabeth M. C. Fisher +11 more
TL;DR: Neuropathology of the Q206H case showed lower motor neuron predominant disease with ubiquitylated inclusions in motor neurons, and antibodies to p62 (sequestosome 1) showed novel oligodendroglialInclusions in the motor cortex.