V
Venugopal Pujari
Researcher at Colorado State University
Publications - 14
Citations - 635
Venugopal Pujari is an academic researcher from Colorado State University. The author has contributed to research in topics: Mycobacterium tuberculosis & Chemistry. The author has an hindex of 10, co-authored 12 publications receiving 543 citations. Previous affiliations of Venugopal Pujari include Indian Institute of Technology Madras.
Papers
More filters
Journal ArticleDOI
Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases
Kai Li,Lici A. Schurig-Briccio,Xinxin Feng,Ashutosh Upadhyay,Venugopal Pujari,Benoit Lechartier,Fabio L. Fontes,Hongliang Yang,Guodong Rao,Wei Zhu,Anmol Gulati,Joo Hwan No,Giovana Aparecida de Souza Cintra,Shannon Bogue,Yi Liang Liu,Katie J. Molohon,Peter Orlean,Douglas A. Mitchell,Lucio H. Freitas-Junior,Feifei Ren,Hong Sun,Tong Jiang,Yujie Li,Rey-Ting Guo,Stewart T. Cole,Robert B. Gennis,Dean C. Crick,Eric Oldfield +27 more
TL;DR: It is shown that 1 and the new compounds also target enzymes involved in menaquinone biosynthesis and electron transport, inhibiting respiration and ATP biosynthesis, and are uncouplers, collapsing the pH gradient and membrane potential used to power transporters.
Journal ArticleDOI
Statistical optimization of medium components for enhanced riboflavin production by a UV-mutant of Eremothecium ashbyii
Venugopal Pujari,T.S. Chandra +1 more
TL;DR: In this paper, the nutritional requirements for riboflavin production by a UV-mutant of Eremothecium ashbyii UV-18-57 were optimized using indigenous agroindustrial byproducts.
Journal ArticleDOI
Inhibition of the First Step in Synthesis of the Mycobacterial Cell Wall Core, Catalyzed by the GlcNAc-1-phosphate Transferase WecA, by the Novel Caprazamycin Derivative CPZEN-45
Yoshimasa Ishizaki,Chigusa Hayashi,Kunio Inoue,Masayuki Igarashi,Yoshiaki Takahashi,Venugopal Pujari,Dean C. Crick,Patrick J. Brennan,Akio Nomoto +8 more
TL;DR: CPZEN-45 inhibits a novel target in cell wall assembly and was effective against WecA, the ortholog of TagO and involved in the biosynthesis of the mycolylarabinogalactan of the cell wall of M. tuberculosis.
Journal ArticleDOI
Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies.
Lisheng Deng,Jiasheng Diao,Pinhong Chen,Venugopal Pujari,Yuan Yao,Gang Cheng,Dean C. Crick,B. V. Venkataram Prasad,Yongcheng Song +8 more
TL;DR: 48 EcDXR inhibitors with a broad chemical diversity were found, however, to generally exhibit considerably reduced activity against Mycobacterium tuberculosis, providing implications in the future design and development of potent DXR inhibitors.
Journal ArticleDOI
Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis.
Anh Tran,Emma E. Watson,Venugopal Pujari,Trent Conroy,Luke J. Dowman,Andrew M. Giltrap,Angel Pang,Weng Ruh Wong,Roger G. Linington,Roger G. Linington,Sebabrata Mahapatra,Jessica Saunders,Susan A. Charman,Nicholas P. West,Timothy D. H. Bugg,Julie A. Tod,Christopher G. Dowson,David I. Roper,Dean C. Crick,Warwick J. Britton,Richard J. Payne +20 more
TL;DR: The rapid synthesis of analogues of the sansanmycin uridylpeptide natural products that represent promising new TB drug leads that operate through the inhibition of peptidoglycan biosynthesis are described.