Weng Ruh Wong

TL;DR: It is demonstrated here that molecular networking, an approach that organizes MS/MS data based on chemical similarity, is a powerful complement to traditional dereplication strategies, and is applied to a diverse array of marine and terrestrial microbial samples.

TL;DR: It is demonstrated that bioactivity fingerprinting is a successful strategy for profiling antibiotic lead compounds and that BioMAP can be applied to the discovery of new natural product antibiotics leads.

TL;DR: This work examines the bacterial communities of fish intestines as a new source of microbial and biosynthetic diversity for natural products discovery, and finds three main clades that show taxonomic divergence from known strains, several of which are previously uncultured.

TL;DR: A global visualization of the detectable molecules produced from a single microorganism, which is defined as the ‘molecular network’ of that organism, is described, followed by studies to characterize the cellular effects of antibacterial molecules.

TL;DR: The rapid synthesis of analogues of the sansanmycin uridylpeptide natural products that represent promising new TB drug leads that operate through the inhibition of peptidoglycan biosynthesis are described.