V
Victoria E. Deneke
Researcher at Duke University
Publications - 12
Citations - 505
Victoria E. Deneke is an academic researcher from Duke University. The author has contributed to research in topics: Biology & Cyclin-dependent kinase. The author has an hindex of 8, co-authored 9 publications receiving 330 citations. Previous affiliations of Victoria E. Deneke include Baylor College of Medicine & University of Notre Dame.
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Journal ArticleDOI
Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos
TL;DR: In Drosophila embryos, Cdk1 positive feedback serves primarily to ensure the rapid onset of mitosis, while wave propagation is regulated by S phase events, demonstrating a fundamental distinction between S phase Cdk 1 waves, which propagate as active trigger waves in an excitable medium, and mitotic Cdk2 waves, who propagate as passive phase waves.
Journal ArticleDOI
Chemical waves in cell and developmental biology
TL;DR: Deneke and Di Talia review how the spatiotemporal coordination of cellular functions across large distances is controlled by chemical waves.
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Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos.
Victoria E. Deneke,Alberto Puliafito,Daniel Krueger,Avaneesh V. Narla,Alessandro De Simone,Luca Primo,Massimo Vergassola,Stefano De Renzis,Stefano Di Talia +8 more
TL;DR: It is shown that synchronization of the cell cycle in Drosophila embryos requires accurate nuclear positioning, which is regulated by the cell-cycle oscillator through cortical contractility and cytoplasmic flows.
Journal ArticleDOI
Mitotic waves in the early embryogenesis of Drosophila: Bistability traded for speed.
TL;DR: This analysis bears upon the inhibition required to suppress Cdk1 waves at the cell-cycle pause for the maternal-to-zygotic transition and generates a wave-like spreading that differs from bistable waves for its dependence on dynamic parameters and its faster speed.
Journal ArticleDOI
CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies.
Woonyung Hur,James P. Kemp,Marco Tarzia,Victoria E. Deneke,William F. Marzluff,Robert J. Duronio,Stefano Di Talia +6 more
TL;DR: The experiments identify a mechanism linking nuclear body growth and size with gene expression and results in smaller HLBs and the appearance of nascent, misprocessed histone mRNAs.