V
Vijayan Manoharan
Researcher at Massachusetts Institute of Technology
Publications - 16
Citations - 3877
Vijayan Manoharan is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Self-healing hydrogels & Tissue engineering. The author has an hindex of 15, co-authored 16 publications receiving 3066 citations. Previous affiliations of Vijayan Manoharan include Shanmugha Arts, Science, Technology & Research Academy & Brigham and Women's Hospital.
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Journal ArticleDOI
Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs
Luiz E. Bertassoni,Luiz E. Bertassoni,Luiz E. Bertassoni,Martina Cecconi,Martina Cecconi,Vijayan Manoharan,Vijayan Manoharan,Mehdi Nikkhah,Mehdi Nikkhah,Jesper Hjortnaes,Jesper Hjortnaes,Ana Luiza Cristino,Ana Luiza Cristino,Giada D. G. Barabaschi,Giada D. G. Barabaschi,Danilo Demarchi,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Yunzhi Yang,Ali Khademhosseini +19 more
TL;DR: A three dimensional micromolding technique utilizing bioprinted agarose template fibers to fabricate microchannel networks with various architectural features within photocrosslinkable hydrogel constructs with useful applications in tissue engineering and organs on a chip is reported.
Journal ArticleDOI
Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low-Viscosity Bioink.
Cristina Colosi,Cristina Colosi,Cristina Colosi,Su Ryon Shin,Su Ryon Shin,Su Ryon Shin,Vijayan Manoharan,Vijayan Manoharan,Solange Massa,Solange Massa,Solange Massa,Marco Costantini,Andrea Barbetta,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Mariella Dentini,Ali Khademhosseini +17 more
TL;DR: A novel bioink and a dispensing technique for 3D tissue-engineering applications are presented, which incorporates a coaxial extrusion needle using a low-viscosity cell-laden bioink to produce highly defined 3D biostructures.
Journal ArticleDOI
Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels
Luiz E. Bertassoni,Luiz E. Bertassoni,Luiz E. Bertassoni,Juliana Cordeiro Cardoso,Juliana Cordeiro Cardoso,Vijayan Manoharan,Vijayan Manoharan,Vijayan Manoharan,Ana Luiza Cristino,Ana Luiza Cristino,Nupura S. Bhise,Nupura S. Bhise,Wesleyan A Araujo,Wesleyan A Araujo,Pinar Zorlutuna,Pinar Zorlutuna,Nihal Engin Vrana,Nihal Engin Vrana,Amir M. Ghaemmaghami,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Ali Khademhosseini,Ali Khademhosseini,Ali Khademhosseini +24 more
TL;DR: This work presents a strategy for direct-write bioprinting of a cell-laden photolabile ECM-derived hydrogel, which may find widespread application for tissue engineering, organ printing and the development of 3D drug discovery platforms.
Journal ArticleDOI
A liver-on-a-chip platform with bioprinted hepatic spheroids.
Nupura S. Bhise,Vijayan Manoharan,Vijayan Manoharan,Solange Massa,Solange Massa,Solange Massa,Ali Tamayol,Ali Tamayol,Masoumeh Ghaderi,Masoumeh Ghaderi,Mario Miscuglio,Mario Miscuglio,Qi Lang,Qi Lang,Yu Shrike Zhang,Yu Shrike Zhang,Su Ryon Shin,Su Ryon Shin,Giovanni Calzone,Giovanni Calzone,Nasim Annabi,Nasim Annabi,Thomas Shupe,Colin E. Bishop,Anthony Atala,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Ali Khademhosseini,Ali Khademhosseini,Ali Khademhosseini +29 more
TL;DR: Treatment with 15 mM acetaminophen induced a toxic response in the hepatic construct that was similar to published studies on animal and other in vitro models, thus providing a proof-of-concept demonstration of the utility of this liver-on-a-chip platform for toxicity assessment.
Journal ArticleDOI
Reduced Graphene Oxide-GelMA Hybrid Hydrogels as Scaffolds for Cardiac Tissue Engineering.
Su Ryon Shin,Su Ryon Shin,Su Ryon Shin,Claudio Zihlmann,Claudio Zihlmann,Mohsen Akbari,Mohsen Akbari,Mohsen Akbari,Pribpandao Assawes,Pribpandao Assawes,Louis Cheung,Kaizhen Zhang,Vijayan Manoharan,Vijayan Manoharan,Yu Shrike Zhang,Yu Shrike Zhang,Mehmet Yuksekkaya,Kai-Tak Wan,Mehdi Nikkhah,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Xiaowu Shirley Tang,Ali Khademhosseini +23 more
TL;DR: The engineered cardiac tissue constructs using rGO incorporated hybrid hydrogels can potentially provide high-fidelity tissue models for drug studies and the investigations of cardiac tissue development and/or disease processes in vitro.