V
Viktor Janzen
Researcher at Harvard University
Publications - 12
Citations - 2353
Viktor Janzen is an academic researcher from Harvard University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 10, co-authored 12 publications receiving 2211 citations. Previous affiliations of Viktor Janzen include Howard Hughes Medical Institute & John Radcliffe Hospital.
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Journal ArticleDOI
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.
Viktor Janzen,Randolf Forkert,Heather E. Fleming,Yoriko Saito,Michael T. Waring,David Dombkowski,Tao Cheng,Tao Cheng,Ronald A. DePinho,Norman E. Sharpless,David T. Scadden +10 more
TL;DR: It is reported that the cyclin-dependent kinase inhibitor p16INK4a accumulates and modulates specific age-associated HSC functions, and may ameliorate the physiological impact of ageing on stem cells and thereby improve injury repair in aged tissue.
Journal ArticleDOI
Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.
Heather E. Fleming,Viktor Janzen,Cristina Lo Celso,Jun Guo,Kathleen M. Leahy,Henry M. Kronenberg,David T. Scadden +6 more
TL;DR: Reduction in HSC Wnt signaling resulted in reduced p21Cip1 expression, increased cell cycling, and a progressive decline in regenerative function after transplantation, which was microenvironment determined, but irreversible if the cells were transferred to a normal host.
Journal ArticleDOI
Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis.
Neil P. Rodrigues,Viktor Janzen,Viktor Janzen,Viktor Janzen,Randolf Forkert,Randolf Forkert,Randolf Forkert,David Dombkowski,David Dombkowski,David Dombkowski,Ashleigh S. Boyd,Ashleigh S. Boyd,Ashleigh S. Boyd,Stuart H. Orkin,Stuart H. Orkin,Stuart H. Orkin,Tariq Enver,Tariq Enver,Tariq Enver,Paresh Vyas,Paresh Vyas,Paresh Vyas,David T. Scadden,David T. Scadden,David T. Scadden +24 more
TL;DR: In this paper, the zinc finger transcription factor GATA-2 plays a fundamental role in generating hematopoietic stem-cells in mammalian development, and the most prominent changes were observed within the stem-cell compartment.
Journal ArticleDOI
Differential H3K4 methylation identifies developmentally poised hematopoietic genes.
Keith W. Orford,Peter V. Kharchenko,Peter V. Kharchenko,Weil R. Lai,Maria Carlota Dao,David J. Worhunsky,Adam Ferro,Viktor Janzen,Peter J. Park,Peter J. Park,David T. Scadden +10 more
TL;DR: Assessment of histone H3 lysine 4 dimethylation and trimethylation on a genome-wide scale in erythroid development reveals distinct epigenetic regulation of CGI and non-CGI genes during development and indicates an interactive relationship between DNA sequence and differential H3K4 methylation in lineage-specific differentiation.
Journal ArticleDOI
Hematopoietic Stem Cell Responsiveness to Exogenous Signals Is Limited by Caspase-3
Viktor Janzen,Heather E. Fleming,Tamara Riedt,Göran Karlsson,Matthew J. Riese,Cristina Lo Celso,Griffin Reynolds,Craig D. Milne,Christopher J. Paige,Stefan Karlsson,Minna Woo,David T. Scadden +11 more
TL;DR: It is reported that the executioner Caspases, Caspase-3, unexpectedly participates in that process that contributes to stem cell quiescence, dampening specific signaling events and thereby cell responsiveness to microenvironmental stimuli.