N
Norman E. Sharpless
Researcher at National Institutes of Health
Publications - 235
Citations - 38454
Norman E. Sharpless is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Senescence. The author has an hindex of 75, co-authored 230 publications receiving 32672 citations. Previous affiliations of Norman E. Sharpless include University of North Carolina at Chapel Hill & Harvard University.
Papers
More filters
Journal ArticleDOI
Circular RNAs are abundant, conserved, and associated with ALU repeats
William R. Jeck,Jessica A. Sorrentino,Kai Wang,Michael K. Slevin,Christin E. Burd,Jinze Liu,William F. Marzluff,Norman E. Sharpless +7 more
TL;DR: High-throughput sequencing of libraries prepared from ribosome-depleted RNA with or without digestion with the RNA exonuclease showed that ecircRNAs are abundant, stable, conserved and nonrandom products of RNA splicing that could be involved in control of gene expression.
Journal ArticleDOI
Genomic Classification of Cutaneous Melanoma
Rehan Akbani,Kadir C. Akdemir,B. Arman Aksoy,Monique Albert,Adrian Ally,Samirkumar B. Amin,Harindra Arachchi,Arshi Arora,J. Todd Auman,Brenda Ayala,Julien Baboud,Miruna Balasundaram,Saianand Balu,Nandita Barnabas,John M. S. Bartlett,Pam Bartlett,Boris C. Bastian,Stephen B. Baylin,Madhusmita Behera,Dmitry Belyaev,Christopher C. Benz,Brady Bernard,Rameen Beroukhim,Natalie Bir,Aaron D. Black,Tom Bodenheimer,Lori Boice,Genevieve M. Boland,Riccardo Bono,Moiz S. Bootwalla,Marcus Bosenberg,Jay Bowen,Reanne Bowlby,Christopher A. Bristow,Laura Brockway-Lunardi,Denise Brooks,Jakub Brzezinski,Wiam Bshara,Elizabeth Buda,William R. Burns,Yaron S.N. Butterfield,Michael Button,Tiffany L. Calderone,Giancarlo Antonini Cappellini,Candace D. Carter,Scott L. Carter,Lynn Cherney,Andrew D. Cherniack,Aaron Chevalier,Lynda Chin,Juok Cho,Raymond J. Cho,Yoon La Choi,Andy Chu,Sudha Chudamani,Kristian Cibulskis,Giovanni Ciriello,Amanda Clarke,Stephen Coons,Leslie Cope,Daniel Crain,Erin Curley,Ludmila Danilova,Stefania D'Atri,Tanja Davidsen,Michael A. Davies,Keith A. Delman,John A. Demchok,Qixia A. Deng,Yonathan Lissanu Deribe,Noreen Dhalla,Rajiv Dhir,Daniel DiCara,Michael Dinikin,Michael Dubina,J. Stephen Ebrom,Sophie Egea,Greg Eley,Jay Engel,Jennifer Eschbacher,Konstantin V. Fedosenko,Ina Felau,Timothy R. Fennell,Martin L. Ferguson,Sheila Fisher,Keith T. Flaherty,Scott Frazer,Jessica Frick,Victoria Fulidou,Stacey Gabriel,Jianjiong Gao,Johanna Gardner,Levi A. Garraway,Julie M. Gastier-Foster,Carmelo Gaudioso,Nils Gehlenborg,Giannicola Genovese,Mark Gerken,Jeffrey E. Gershenwald,Gad Getz,Carmen Gomez-Fernandez,Thomas Gribbin,Jonna Grimsby,Benjamin Gross,Ranabir Guin,Tony Gutschner,Angela Hadjipanayis,Ruth Halaban,Benjamin Hanf,David Haussler,Lauren E. Haydu,D. Neil Hayes,Nicholas K. Hayward,David I. Heiman,Lynn M. Herbert,James G. Herman,Peter Hersey,Katherine A. Hoadley,Eran Hodis,Robert A. Holt,Dave S.B. Hoon,Susan Hoppough,Alan P. Hoyle,Franklin W. Huang,Mei Huang,Sharon K. Huang,Carolyn M. Hutter,Matthew Ibbs,Lisa Iype,Anders Jacobsen,Valerie Jakrot,Alyssa Janning,William R. Jeck,Stuart R. Jefferys,Mark A. Jensen,Corbin D. Jones,Steven J.M. Jones,Zhenlin Ju,Hojabr Kakavand,Hyojin Kang,Richard F. Kefford,Fadlo R. Khuri,Jaegil Kim,John M. Kirkwood,Joachim Klode,Anil Korkut,Konstanty Korski,Michael Krauthammer,Raju Kucherlapati,Lawrence N. Kwong,Witold Kycler,Marc Ladanyi,Phillip H. Lai,Peter W. Laird,Eric S. Lander,Michael S. Lawrence,Alexander J. Lazar,Radoslaw Łaźniak,Darlene Lee,Jeffrey E. Lee,Junehawk Lee,Kenneth K. Lee,Semin Lee,William Lee,Ewa Leporowska,Kristen M. Leraas,Haiyan I. Li,Tara M. Lichtenberg,Lee Lichtenstein,Pei Lin,Shiyun Ling,Jia Liu,Ouida Liu,Wen-Bin Liu,Georgina V. Long,Yiling Lu,Singer Ma,Yussanne Ma,Andrzej Mackiewicz,Harshad S. Mahadeshwar,Jared Malke,David Mallery,Georgy Manikhas,Graham J. Mann,Marco A. Marra,Brenna Matejka,Michael Mayo,Sousan Mehrabi,Shaowu Meng,Matthew Meyerson,Piotr A. Mieczkowski,John P. Miller,Martin L. Miller,Gordon B. Mills,Fedor Moiseenko,Richard A. Moore,Scott Morris,Carl Morrison,Donald L. Morton,Stergios J. Moschos,Lisle E. Mose,Florian L. Muller,Andrew J. Mungall,D. Murawa,Pawel Murawa,Bradley A. Murray,Luigi Nezi,Sam Ng,Dana Nicholson,Michael S. Noble,Adeboye Osunkoya,Taofeek K. Owonikoko,Bradley A. Ozenberger,Elena Pagani,Oxana Paklina,Angeliki Pantazi,Michael Parfenov,Jeremy Parfitt,Peter J. Park,Woong-Yang Park,Joel S. Parker,Francesca Passarelli,Robert Penny,Charles M. Perou,Todd Pihl,Olga Potapova,Victor G. Prieto,Alexei Protopopov,Michael J. Quinn,Amie Radenbaugh,Kunal Rai,Suresh Ramalingam,Ayush T. Raman,Nilsa C. Ramirez,Ricardo Ramirez,Uma Rao,W. Kimryn Rathmell,Xiaojia Ren,Sheila Reynolds,Jeffrey Roach,A. Gordon Robertson,Merrick I. Ross,Jason Roszik,Giandomenico Russo,Gordon Saksena,Charles Saller,Yardena Samuels,Chris Sander,Cindy Sander,George E. Sandusky,Netty Santoso,Melissa Saul,Robyn P. M. Saw,Dirk Schadendorf,Jacqueline E. Schein,Nikolaus Schultz,Steven E. Schumacher,Charles Schwallier,Richard A. Scolyer,Jonathan G. Seidman,Pedamallu Chandra Sekhar,Harmanjatinder S. Sekhon,Yasin Senbabaoglu,Sahil Seth,Kerwin F. Shannon,Samantha Sharpe,Norman E. Sharpless,Kenna R. Mills Shaw,Candace Shelton,Troy Shelton,Ronglai Shen,Margi Sheth,Yan Shi,Carolyn J. Shiau,Ilya Shmulevich,Gabriel Sica,Janae V. Simons,Rileen Sinha,Payal Sipahimalani,Heidi J. Sofia,Matthew G. Soloway,Xingzhi Song,Carrie Sougnez,Andrew J. Spillane,Arkadiusz Spychała,Jonathan R. Stretch,Joshua M. Stuart,Wiktoria Maria Suchorska,Antje Sucker,S. Onur Sumer,Yichao Sun,Maria Synott,Barbara Tabak,Teresa R. Tabler,Angela Tam,Donghui Tan,Jiabin Tang,Roy Tarnuzzer,Katherine Tarvin,Honorata Tatka,Barry S. Taylor,M. Teresiak,Nina Thiessen,John F. Thompson,Leigh B. Thorne,Vesteinn Thorsson,Jeffrey M. Trent,Timothy J. Triche,Kenneth Y. Tsai,Peiling Tsou,David Van Den Berg,Eliezer M. Van Allen,Umadevi Veluvolu,Roeland Verhaak,Douglas Voet,Olga Voronina,Vonn Walter,Jessica Walton,Yunhu Wan,Yuling Wang,Zhining Wang,Scot Waring,Ian R. Watson,Nils Weinhold,John N. Weinstein,Daniel J. Weisenberger,Peter White,Matthew D. Wilkerson,James S. Wilmott,Lisa Wise,Maciej Wiznerowicz,Scott E. Woodman,Chang Jiun Wu,Chia Chin Wu,Junyuan Wu,Ye Wu,Ruibin Xi,Andrew Wei Xu,Da Yang,Liming Yang,Lixing Yang,Travis I. Zack,Jean C. Zenklusen,Hailei Zhang,Jianhua Zhang,Wei Zhang,Xiaobei Zhao,Jingchun Zhu,Kelsey Zhu,Lisa Zimmer,Erik Zmuda,Lihua Zou +351 more
TL;DR: This clinicopathological and multi-dimensional analysis suggests that the prognosis of melanoma patients with regional metastases is influenced by tumor stroma immunobiology, offering insights to further personalize therapeutic decision-making.
Journal ArticleDOI
Detecting and characterizing circular RNAs
TL;DR: Evidence is emerging that some circRNAs might regulate microRNA (miRNA) function, and roles in transcriptional control have also been suggested.
Journal ArticleDOI
Ink4a/Arf expression is a biomarker of aging
Janakiraman Krishnamurthy,Chad Torrice,Matthew R. Ramsey,Grigoriy I. Kovalev,Khalid A. Al-Regaiey,Lishan Su,Norman E. Sharpless +6 more
TL;DR: In this article, the authors examined the links between senescence and aging in vivo, and showed that expression of p16INK4a and Arf markedly increases in almost all rodent tissues with advancing age, while there is little or no change in the expression of related cell cycle inhibitors.
Journal ArticleDOI
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
Jianhui Chang,Yingying Wang,Yingying Wang,Lijian Shao,Remi-Martin Laberge,Marco Demaria,Judith Campisi,Judith Campisi,Krishnamurthy Janakiraman,Norman E. Sharpless,Sheng Ding,Wei Feng,Yi Luo,Xiaoyan Wang,Nukhet Aykin-Burns,Kimberly J. Krager,Usha Ponnappan,Martin Hauer-Jensen,Aimin Meng,Daohong Zhou +19 more
TL;DR: It is demonstrated that selective clearance of SCs by a pharmacological agent is beneficial in part through its rejuvenation of aged tissue stem cells, demonstrating that senolytic drugs may represent a new class of radiation mitigators and anti-aging agents.