Viktor von Wyl

TL;DR: The purpose of this report is to update researchers on the progress of the WIHS and to provide information on WIHS resources, the methods by which they were obtained, and background for any new potential researchers interested in conducting collaborative research through shared use of these resources.

TL;DR: It is estimated that cART halved the average mortality rate in HIV-infected individuals and was greater in those with worse prognosis at the start of follow-up.

TL;DR: Findings confirm present treatment guidelines for HIV, which state that the initial treatment choice should be based on resistance testing in treatment-naive patients, that the effect of TDR on outcome in the first year of cART is confirmed.

TL;DR: The need for cheap point-of-care viral-load tests to identify early viral failures and limit the emergence of resistance is highlighted, with genotypic resistance at 48 weeks to lamivudine, nucleoside reverse transcriptase inhibitors (thymidine analogue mutations), and non-nucleoside Reverse Transcriptase inhibitors appears substantially higher in less frequently monitored patients.

TL;DR: Initiation of cART at a threshold CD4 count of 0.500 × 10(9) cells/L increases AIDS-free survival, and mortality did not vary substantially with the use of CD4 thresholds between 0.300 and 0.200, while Residual confounding may exist.