R
Ravindra K. Gupta
Researcher at University of Cambridge
Publications - 171
Citations - 14576
Ravindra K. Gupta is an academic researcher from University of Cambridge. The author has contributed to research in topics: Medicine & Viral load. The author has an hindex of 38, co-authored 144 publications receiving 6658 citations. Previous affiliations of Ravindra K. Gupta include John Radcliffe Hospital & University College London Hospitals NHS Foundation Trust.
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Journal ArticleDOI
SARS-CoV-2 variants, spike mutations and immune escape.
William T. Harvey,Alessandro M Carabelli,Ben Jackson,Ravindra K. Gupta,E. Thomson,E. Thomson,Ewan M. Harrison,Ewan M. Harrison,Catherine Ludden,Richard Reeve,Andrew Rambaut,Sharon J. Peacock,David Robertson +12 more
TL;DR: A review of the literature on mutations of the SARS-CoV-2 spike protein, the primary antigen, focusing on their impacts on antigenicity and contextualizing them in the protein structure is presented in this article.
Journal ArticleDOI
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion.
Petra Mlcochova,Steven Kemp,Steven Kemp,Mahesh Shanker Dhar,Guido Papa,Bo Meng,Isabella Ferreira,Rawlings Datir,Dami A. Collier,Dami A. Collier,Anna Albecka,Sujeet Kumar Singh,Rajesh Pandey,Jonathan Brown,Jie Zhou,Niluka Goonawardane,Swapnil Mishra,Charles Whittaker,Thomas A. Mellan,Robin Marwal,Meena Datta,Shantanu Sengupta,Kalaiarasan Ponnusamy,V. S. Radhakrishnan,Adam Abdullahi,Oscar Charles,Partha Chattopadhyay,Priti Devi,Daniela Caputo,Thomas P. Peacock,Chand Wattal,Neeraj Goel,Ambrish Satwik,Raju Vaishya,Meenakshi Agarwal,Antranik Mavousian,Joo-Hyeon Lee,Jessica Bassi,Chiara Silacci-Fegni,Christian Saliba,Dora Pinto,Takashi Irie,Isao Yoshida,William L Hamilton,Kei Sato,Samir Bhatt,Samir Bhatt,Seth Flaxman,Leo C. James,Davide Corti,Luca Piccoli,Wendy S. Barclay,Partha Rakshit,Anurag Agrawal,Ravindra K. Gupta +54 more
TL;DR: The B.617.1.2 spike protein was able to mediate highly efficient syncytium formation that was less sensitive to inhibition by neutralizing antibody, compared with that of wild-type spike as discussed by the authors.
Journal ArticleDOI
The “Silent” Global Burden of Congenital Cytomegalovirus
TL;DR: The global epidemiology of congenital CMV and the implications of growing knowledge in areas of prevention, diagnosis, prognosis, and management for both low (50 to 70%)- and high (>70%)-seroprevalence settings are highlighted.
Journal ArticleDOI
SARS-CoV-2 evolution during treatment of chronic infection.
Steven Kemp,Dami A. Collier,Dami A. Collier,Rawlings Datir,Isabella Ferreira,Salma Gayed,Aminu S Jahun,Myra Hosmillo,Chloe Rees-Spear,Petra Mlcochova,Ines Ushiro Lumb,David J. Roberts,Anita Chandra,Nigel J. Temperton,Katherine Sharrocks,Elizabeth Blane,Yorgo Modis,Yorgo Modis,Kendra E. Leigh,Kendra E. Leigh,John A. G. Briggs,Marit J. van Gils,Kenneth G. C. Smith,John Bradley,Chris Smith,Rainer Doffinger,Lourdes Ceron-Gutierrez,Gabriela Barcenas-Morales,David D. Pollock,Richard A. Goldstein,Anna Smielewska,Jordan P. Skittrall,Theodore Gouliouris,Ian Goodfellow,Effrossyni Gkrania-Klotsas,Christopher J. R. Illingworth,Laura E. McCoy,Ravindra K. Gupta +37 more
TL;DR: In this paper, the authors report chronic SARS-CoV-2 with reduced sensitivity to neutralizing antibodies in an immune suppressed individual treated with convalescent plasma, generating whole genome ultradeep sequences over 23 time points spanning 101 days.
Journal ArticleDOI
The biological and clinical significance of emerging SARS-CoV-2 variants.
Kaiming Tao,Philip L Tzou,Janin Nouhin,Ravindra K. Gupta,Tulio de Oliveira,Sergei L Kosakovsky Pond,Daniela Fera,Robert W. Shafer +7 more
TL;DR: The emergence of SARS-CoV-2 variants with novel spike protein mutations that are influencing the epidemiological and clinical aspects of the COVID-19 pandemic has been witnessed as mentioned in this paper.