V
Vincent Gagné
Researcher at Université de Montréal
Publications - 22
Citations - 769
Vincent Gagné is an academic researcher from Université de Montréal. The author has contributed to research in topics: Childhood Acute Lymphoblastic Leukemia & Haplotype. The author has an hindex of 12, co-authored 19 publications receiving 692 citations. Previous affiliations of Vincent Gagné include Brigham and Women's Hospital & Centre Hospitalier Universitaire Sainte-Justine.
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Journal ArticleDOI
Global patterns of cis variation in human cells revealed by high-density allelic expression analysis
Bing Ge,Dmitry K. Pokholok,Tony Kwan,Elin Grundberg,Lisanne Morcos,Dominique J. Verlaan,Jennie M. Le,Vonda Koka,Kevin C. L. Lam,Vincent Gagné,Joana Dias,Rose Hoberman,Alexandre Montpetit,Marie Michele Joly,Edward J. Harvey,Daniel Sinnett,Patrick Beaulieu,Robert Hamon,Alexandru Graziani,Ken Dewar,Eef Harmsen,Jacek Majewski,Harald H H Göring,Anna K. Naumova,Mathieu Blanchette,Kevin L. Gunderson,Tomi Pastinen +26 more
TL;DR: A map of AE associated SNPs is generated using quantitative measurements of AE on Illumina Human1M BeadChips to identify common cis variants affecting 30% (2935/9751) of the measured RefSeq transcripts at 0.001 permutation significance.
Journal ArticleDOI
DNA variants in the dihydrofolate reductase gene and outcome in childhood ALL.
Stéphanie Dulucq,Geneviève St-Onge,Vincent Gagné,Marc Ansari,Daniel Sinnett,Damian Labuda,Albert Moghrabi,Maja Krajinovic +7 more
TL;DR: In conclusion, DHFR promoter polymorphisms are associated with worse ALL outcome, likely due to a higher DHFR expression.
Journal ArticleDOI
Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia
Marc Ansari,Geraldine Sauty,Malgorzata Labuda,Vincent Gagné,Caroline Laverdière,Albert Moghrabi,Daniel Sinnett,Maja Krajinovic,Maja Krajinovic +8 more
TL;DR: Gene reporter assay showed that the promoter haplotype uniquely tagged by the C-1393 allele conferred higher promoter activity compared with remaining haplotypes, and further analyses are needed to replicate this pilot study and get closer insight into the functional effect of these polymorphisms.
Journal ArticleDOI
Polymorphisms of the vincristine pathway and response to treatment in children with childhood acute lymphoblastic leukemia
Francesco Ceppi,Chloé Langlois-Pelletier,Vincent Gagné,Julie Rousseau,Claire Ciolino,Samanta De Lorenzo,Kojok M Kevin,Diana Cijov,Stephen E. Sallan,Stephen E. Sallan,Lewis B. Silverman,Lewis B. Silverman,Donna Neuberg,Jeffery L. Kutok,Daniel Sinnett,Caroline Laverdière,Maja Krajinovic +16 more
TL;DR: The polymorphisms in the ACTG1, CAPG and ABCB1 genes may modulate VCR-related neurotoxicity, whereas the risk of relapse seems not to be affected by the genes of the VCR pathway.
Journal ArticleDOI
Polymorphisms of Asparaginase Pathway and Asparaginase-Related Complications in Children with Acute Lymphoblastic Leukemia
Mohsen Ben Tanfous,Bahram Sharif-Askari,Francesco Ceppi,Haithem Laaribi,Vincent Gagné,Julie Rousseau,Malgorzata Labuda,Lewis B. Silverman,Stephen E. Sallan,Donna Neuberg,Jeffery L. Kutok,Daniel Sinnett,Caroline Laverdière,Maja Krajinovic +13 more
TL;DR: Among patients of the discovery group, allergies, and pancreatitis were more frequent in individuals who are homozygous for the triple-repeat allele (3R) of the asparagine synthetase (ASNS) gene, resulting in remarkably higher risk of these toxicities associated with 3R3R genotype.