Bing Ge

TL;DR: A genome-wide association analysis in the UK Biobank and INTERVAL studies is performed, providing evidence of shared genetic pathways linking blood cell indices with complex pathologies, including autoimmune diseases, schizophrenia, and coronary heart disease and evidence suggesting previously reported population associations betweenBlood cell indices and cardiovascular disease may be non-causal.

TL;DR: High-resolution genetic, epigenetic, and transcriptomic profiling in three major human immune cell types from up to 197 individuals yields insights into cell-type-specific correlation between diverse genomic inputs, more generalizable correlations between these inputs, and defines molecular events that may underpin complex disease risk.

TL;DR: In this article, the authors report the joint analysis of sequence variants, gene expression and DNA methylation in primary fibroblast samples derived from a set of 62 unrelated individuals, with considerable involvement of chromatin features and some discernible involvement of sequence variation.

TL;DR: Evidence is provided that low‐frequency non‐coding variants have large effects on BMD and fracture, thereby providing rationale for whole‐genome sequencing and improved imputation reference panels to study the genetic architecture of complex traits and disease in the general population.

TL;DR: The cloning of this gene, SACS, which encodes the protein sacsin, which is the largest to be identified in any vertebrate organism is reported, and the presence of heat-shock domains suggests a function for sacsin in chaperone-mediated protein folding.