V
Virginia Chu
Researcher at University of California, Los Angeles
Publications - 8
Citations - 461
Virginia Chu is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 7, co-authored 7 publications receiving 391 citations. Previous affiliations of Virginia Chu include National Institutes of Health.
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Journal ArticleDOI
Engrafted human stem cell–derived hepatocytes establish an infectious HCV murine model
Arnaud Carpentier,Abeba Tesfaye,Virginia Chu,Ila Nimgaonkar,Fang Zhang,Seung Bum Lee,Snorri S. Thorgeirsson,Stephen M. Feinstone,T. Jake Liang +8 more
TL;DR: It is determined that, despite an immature phenotype, differentiated HLCs are permissive to hepatitis C virus (HCV) infection and mount an interferon response to HCV infection in vitro.
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Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection
Shanshan He,Billy Lin,Virginia Chu,Zongyi Hu,Xin Hu,Jingbo Xiao,Amy Wang,Cameron J. Schweitzer,Qisheng Li,Michio Imamura,Nobuhiko Hiraga,Noel Southall,Marc Ferrer,Wei Zheng,Kazuaki Chayama,Juan J. Marugan,T. Jake Liang +16 more
TL;DR: Chlorcyclizine HCl (CCZ), an over-the-counter drug for allergy symptoms, is identified and characterized as an anti-HCV drug in vitro and in vivo, and represents a promising candidate for drug repurposing and further development as an effective and accessible agent for treatment of HCV infection.
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A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivity.
Hangfei Qi,C. Anders Olson,Nicholas C. Wu,Ruian Ke,Claude Loverdo,Virginia Chu,Shawna Truong,Roland Remenyi,Zugen Chen,Yushen Du,Sheng Yao Su,Laith Q. Al-Mawsawi,Ting-Ting Wu,Shu Hua Chen,Chung Yen Lin,Weidong Zhong,James O. Lloyd-Smith,Ren Sun +17 more
TL;DR: This high-resolution profiling methodology will be useful for next-generation drug development to select drugs with higher fitness costs to resistance, and also for informing the rational use of drugs based on viral variant spectra from patients.
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Hepatic differentiation of human pluripotent stem cells in miniaturized format suitable for high-throughput screen.
TL;DR: This protocol affords the unique opportunity to miniaturize the hPSC-based differentiation technology and facilitates screening for molecules in modulating liver differentiation, metabolism, genetic network, and response to infection or other external stimuli.
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Systematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein.
Hangfei Qi,Virginia Chu,Nicholas C. Wu,Zugen Chen,Shawna Truong,Gurpreet Brar,Sheng Yao Su,Sheng Yao Su,Yushen Du,Yushen Du,Vaithilingaraja Arumugaswami,C. Anders Olson,Shu Hua Chen,Chung Yen Lin,Ting-Ting Wu,Ren Sun,Ren Sun +16 more
TL;DR: In this paper, a high-throughput profiling platform was developed to enable mapping of hepatitis C virus (HCV) sequences critical for anti-IFN function at high resolution, and it was found that p7 is a critical immune evasion protein that suppresses the antiviral IFN function by counteracting the function of IFI6-16.