Virginia Zorita

TL;DR: It is shown that inactivating mutations in the epigenetic regulator TET2, which lead to clonal hematopoiesis, aggravate age- and obesity-related insulin resistance in mice, and this metabolic dysfunction is paralleled by increased expression of the pro-inflammatory cytokine IL-1β in white adipose tissue, and it is suppressed by pharmacological inhibition of NLRP3 inflammasome-mediated IL- 1β production.

TL;DR: The venomics study shows that, despite the broad geographic distribution of the genus, monospecific antivenoms may achieve clinical coverage for any Lachesis sp.

TL;DR: It is shown that CD9 regulates the T cell-stimulatory capacity of granulocyte-macrophage colony-stimulating factor-dependent bone marrow-derived DCs (BMDCs), without affecting antigen presentation by fms-like tyrosine kinase 3 ligand (Flt3L)-dependent BMDCs.

TL;DR: It is demonstrated that disruption of the CCL1-CCR8 axis promotes atherosclerosis by inhibiting interleukin 10 production and Treg recruitment and function.

TL;DR: It is demonstrated that the absence of lamin A/C in naive T-cell reduces Th1 differentiation without affecting Th2 differentiation in vitro and in vivo, and reveals a novel role for lamin C/C as key regulator of Th 1 differentiation in response to viral and intracellular parasite infections.