V
Vito Alessandro Lasorsa
Researcher at University of Naples Federico II
Publications - 41
Citations - 582
Vito Alessandro Lasorsa is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 27 publications receiving 293 citations.
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Journal ArticleDOI
Exome and deep sequencing of clinically aggressive neuroblastoma reveal somatic mutations that affect key pathways involved in cancer progression.
Vito Alessandro Lasorsa,Daniela Formicola,Piero Pignataro,Flora Cimmino,Francesco Maria Calabrese,Jaume Mora,Maria Rosaria Esposito,Marcella Pantile,Carlo Zanon,Marilena De Mariano,Luca Longo,Michael D. Hogarty,Carmen Torres,Gian Paolo Tonini,Achille Iolascon,Mario Capasso +15 more
TL;DR: The analyses show pathway-level implications of infrequently mutated genes in leading neuroblastoma progression, and Notably BARD1, CHEK2 and AXIN2 were enriched in rare, potentially pathogenic, germline variants.
Journal ArticleDOI
HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia
Flora Cimmino,Marianna Avitabile,Vito Alessandro Lasorsa,Annalaura Montella,Lucia Pezone,Sueva Cantalupo,Feliciano Visconte,Maria Valeria Corrias,Achille Iolascon,Mario Capasso +9 more
TL;DR: A combined analysis of RNA expression and DNA methylation of neuroblastoma cells silenced or unsilenced for HIF1A expression may help to understand the molecular mechanisms by which low oxygen levels reshape gene signatures and provide new direction for hypoxia targeting in solid tumor.
Journal ArticleDOI
Common variants at 21q22.3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19.
Immacolata Andolfo,Roberta Russo,Vito Alessandro Lasorsa,Sueva Cantalupo,Barbara Eleni Rosato,Ferdinando Bonfiglio,Giulia Frisso,Pasquale Abete,Gian Marco Cassese,Giuseppe Servillo,Gabriella Esposito,Ivan Gentile,Carmelo Piscopo,Romolo Villani,Giuseppe Fiorentino,Pellegrino Cerino,Carlo Buonerba,Biancamaria Pierri,Massimo Zollo,Achille Iolascon,Mario Capasso +20 more
TL;DR: In this article, the authors performed an in-depth genetic analysis of chromosome 21 exploiting the genome-wide association study data, including 6,406 individuals hospitalized for COVID-19 and 902,088 controls with European genetic ancestry from the COVID19 Host Genetics Initiative.
Journal ArticleDOI
An 18 gene expression‑based score classifier predicts the clinical outcome in stage 4 neuroblastoma
Daniela Formicola,Giuseppe Petrosino,Vito Alessandro Lasorsa,Piero Pignataro,Flora Cimmino,Simona Vetrella,Luca Longo,Gian Paolo Tonini,André Oberthuer,Achille Iolascon,Matthias Fischer,Matthias Fischer,Mario Capasso +12 more
TL;DR: Using microarray analyses of 342 primary tumors, the authors developed and validated an easy to use gene expression-based risk score including 18 genes, which can robustly predict the outcome of stage 4 patients.
An 18 gene expression-based score classifier predicts the clinical outcome in stage 4
Giuseppe Petrosino,Vito Alessandro Lasorsa,Piero Pignataro,Flora Cimmino,Simona Vetrella,Luca Longo,Gian Paolo Tonini,André Oberthuer,Achille Iolascon,Matthias Fischer,Mario Capasso +10 more
TL;DR: Together, the 18-gene risk score classifier can identify patients with stage 4 NB with favorable outcome and may therefore improve risk assessment and treatment stratification of NB patients with disseminated disease.