V
Viviana Costa
Publications - 42
Citations - 1284
Viviana Costa is an academic researcher. The author has contributed to research in topics: Cellular differentiation & Mesenchymal stem cell. The author has an hindex of 17, co-authored 37 publications receiving 882 citations.
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Journal ArticleDOI
CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA
Alice Conigliaro,Viviana Costa,Alessia Lo Dico,Laura Saieva,Simona Buccheri,Francesco Dieli,Mauro Manno,Samuele Raccosta,Carmine Mancone,Marco Tripodi,Giacomo De Leo,Riccardo Alessandro,Riccardo Alessandro +12 more
TL;DR: A new exosome-mediated mechanism by which CSC-like CD90+ cells could influence their tumor microenvironment by promoting angiogenic phenotype and cell-to-cell adhesion is indicated.
Journal ArticleDOI
Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis.
Daniele Bellavia,A. De Luca,Valeria Carina,Viviana Costa,Lavinia Raimondi,Francesca Salamanna,Riccardo Alessandro,Milena Fini,Gianluca Giavaresi +8 more
TL;DR: An exhaustive overview of miRNAs with experimentally validated targets involved in bone homeostasis and highlight their possible role in osteoporosis development is given.
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Osteosarcoma cell-derived exosomes affect tumor microenvironment by specific packaging of microRNAs
Lavinia Raimondi,Angela De Luca,Alessia Gallo,Viviana Costa,Giovanna Russelli,Nicola Cuscino,Mauro Manno,Samuele Raccosta,Valeria Carina,Daniele Bellavia,Alice Conigliaro,Riccardo Alessandro,Milena Fini,Pier Giulio Conaldi,Gianluca Giavaresi +14 more
TL;DR: In this paper, the authors investigated the contribution of exosomes inside the micro-environment, and found that exosome promoted osteoclasts differentiation and bone resorption activity and increased angiogenic markers expression.
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A new bi-layered scaffold for osteochondral tissue regeneration: In vitro and in vivo preclinical investigations.
Maria Sartori,Stefania Pagani,A. Ferrari,Viviana Costa,Valeria Carina,E. Figallo,M C Maltarello,Lucia Martini,Milena Fini,Gianluca Giavaresi +9 more
TL;DR: The in vivo results further confirmed the great potential of the scaffold in tissue engineering, as it was able to support the initial formation of new bone and chondral tissue, confirming the importance of combined and innovative strategies to improve the available therapeutic strategies for chondRAL and osteochondral regeneration.
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MiR675-5p acts on HIF-1α to sustain hypoxic responses: A new therapeutic strategy for glioma
Alessia Lo Dico,Viviana Costa,Cristina Martelli,Cecilia Diceglie,Francesca Rajata,Aroldo Rizzo,Carmine Mancone,Marco Tripodi,Luisa Ottobrini,Riccardo Alessandro,Alice Conigliaro +10 more
TL;DR: It is described, for the first time, that miR675-5p, embedded in hypoxia-induced long non-coding RNA H19, plays a mandatory role in establishing a hypoxic response and in promoting hypoxIA-mediated angiogenesis.