V
Vladimir S. Prassolov
Researcher at Engelhardt Institute of Molecular Biology
Publications - 98
Citations - 1698
Vladimir S. Prassolov is an academic researcher from Engelhardt Institute of Molecular Biology. The author has contributed to research in topics: Gene & RNA interference. The author has an hindex of 21, co-authored 89 publications receiving 1428 citations. Previous affiliations of Vladimir S. Prassolov include National Cancer Research Institute & Russian Academy of Sciences.
Papers
More filters
Journal ArticleDOI
Efficient Translation Initiation Directed by the 900-Nucleotide-Long and GC-Rich 5 Untranslated Region of the Human Retrotransposon LINE-1 mRNA Is Strictly Cap Dependent Rather than Internal Ribosome Entry Site Mediated
Sergey E. Dmitriev,Dmitri E. Andreev,Ilya M. Terenin,Ivan Olovnikov,Vladimir S. Prassolov,William C. Merrick,Ivan N. Shatsky +6 more
TL;DR: Current ideas on mechanisms used by 40S ribosomal subunits to cope with complex 5′UTRs are modified and called into question the conception that every long GC-rich5′UTR working with a high efficiency has to contain an IRES.
Journal ArticleDOI
Distinctive Properties of the 5′-Untranslated Region of Human Hsp70 mRNA
M. P. Rubtsova,Daria Sizova,Sergei E. Dmitriev,Dmitri S. Ivanov,Vladimir S. Prassolov,Ivan N. Shatsky +5 more
TL;DR: It is shown that the 216-nt long 5′-UTR of Hsp70 mRNA acts as an IRES that directs ribosomes to the downstream start codon by a cap-independent mechanism, and that the IRES activity requires integrity of almost the entire sequence of the 5′ -UTR.
Journal ArticleDOI
Local administration of cells containing an inserted IL-2 gene and producing IL-2 inhibits growth of human tumours in nu/nu mice.
Bubeník J,Nikolai N. Voitenok,J. Kieler,Vladimir S. Prassolov,Peter M. Chumakov,D. Bubenikova,J. Šimová,Jandlová T +7 more
TL;DR: Peritumoral administration of IL-2-producing RAT-1 cells into congenitally athymic (nu/nu) mice carrying subcutaneous transplants of human carcinoma cells inhibited the growth of the human tumour xenografts.
Journal ArticleDOI
Differential contribution of the m7G-cap to the 5′ end-dependent translation initiation of mammalian mRNAs
Dmitri E. Andreev,Sergey E. Dmitriev,Ilya M. Terenin,Vladimir S. Prassolov,William C. Merrick,Ivan N. Shatsky +5 more
TL;DR: It is not mandatory to invoke the IRES hypothesis, at least for some mRNAs, to explain their preferential translation when eIF4E is partially inactivated, because in cultured cells or cytoplasmic extracts both the level of stimulation with the cap and the overall translation activity do not correlate with the cumulative energy of the secondary structure of the tested 5′ UTRs.
Journal ArticleDOI
Atlas of RNA sequencing profiles for normal human tissues.
Maria Suntsova,Nurshat Gaifullin,Daria Allina,Alexey Reshetun,Xinmin Li,Larisa Mendeleeva,V. L. Surin,Anna Sergeeva,Pavel Spirin,Vladimir S. Prassolov,Alexander Morgan,Andrew Garazha,Maxim Sorokin,Anton Buzdin +13 more
TL;DR: The gene expression database of normal human tissues based on uniformly screened original sequencing data was constructed and deposited, finding that overall 463 biosamples showed tissue-specific rather than platform- or database-specific clustering and could be aggregated in a single database termed Oncobox Atlas of Normal Tissue Expression (ANTE).