V
Vu Thuy Khanh Le
Researcher at University of Düsseldorf
Publications - 15
Citations - 1271
Vu Thuy Khanh Le is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Human cytomegalovirus & Immune system. The author has an hindex of 13, co-authored 15 publications receiving 1133 citations. Previous affiliations of Vu Thuy Khanh Le include University of Duisburg-Essen.
Papers
More filters
Journal ArticleDOI
Decoding Human Cytomegalovirus
Noam Stern-Ginossar,Ben Weisburd,Annette Michalski,Vu Thuy Khanh Le,Marco Y. Hein,Sheng-Xiong Huang,Ming Ma,Ben Shen,Shu-Bing Qian,Hartmut Hengel,Matthias Mann,Nicholas T. Ingolia,Jonathan S. Weissman +12 more
TL;DR: The results reveal an unanticipated complexity to the HCMV coding capacity and illustrate the role of regulated changes in transcript start sites in generating this complexity.
Journal ArticleDOI
IL-12–producing monocytes and HLA-E control HCMV-driven NKG2C + NK cell expansion
Alexander Rölle,Julia Pollmann,Eva Maria Ewen,Vu Thuy Khanh Le,Anne Halenius,Hartmut Hengel,Adelheid Cerwenka +6 more
TL;DR: Together, the results reveal that IL-12, CD14(+) cells, and the CD94/NKG2C/HLA-E axis are critical for the expansion of NKG 2C(+) NK cells in response to HCMV infection.
Journal ArticleDOI
The Cytomegaloviral Protein pUL138 Acts as Potentiator of Tumor Necrosis Factor (TNF) Receptor 1 Surface Density To Enhance ULb′-Encoded Modulation of TNF-α Signaling
TL;DR: This work has identified the latency-associated gene product pUL138, which also is expressed during productive infection, as a selective potentiator of tumor necrosis factor receptor 1, one of the key receptors of innate immunity, and identifies this region as a hub for multilayered tumor Necrosis factor alpha signaling regulation.
Journal ArticleDOI
Human cytomegalovirus interferes with signal transducer and activator of transcription (STAT) 2 protein stability and tyrosine phosphorylation
TL;DR: HCMV abrogates IFN receptor signalling at multiple checkpoints by independent mechanisms including UL27-independent degradation of STAT2 and a preceding blockade ofstat2 phosphorylation, suggesting degradation ofSTAT2 via the ubiquitin proteasome pathway.
Journal ArticleDOI
Human cytomegalovirus Fcγ binding proteins gp34 and gp68 antagonize Fcγ receptors I, II and III.
Eugenia Corrales-Aguilar,Mirko Trilling,Katja Hunold,Manuela Fiedler,Vu Thuy Khanh Le,Henrike Reinhard,Katrin Ehrhardt,Eva Mercé-Maldonado,Enver Aliyev,Albert Zimmermann,David C. Johnson,Hartmut Hengel +11 more
TL;DR: Surface immune-precipitation showed that both HCMV-encoded Fcγ binding proteins have the capacity to bind trastuzumab antibody-HER2 antigen complexes demonstrating simultaneous linkage of immune IgG with antigen and the H CMV inhibitors on the plasma membrane.