W
W.-D. Ludwig
Researcher at Charité
Publications - 123
Citations - 5013
W.-D. Ludwig is an academic researcher from Charité. The author has contributed to research in topics: Leukemia & Myeloid leukemia. The author has an hindex of 34, co-authored 123 publications receiving 4806 citations. Previous affiliations of W.-D. Ludwig include Humboldt University of Berlin & Free University of Berlin.
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Journal ArticleDOI
Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Münster.
Martin Schrappe,A. Reiter,Martin Zimmermann,Jochen Harbott,W.-D. Ludwig,Günter Henze,Helmut Gadner,E. Odenwald,Hansjörg Riehm +8 more
TL;DR: While it has proven so far to be impossible to improve the outcome for the small group of high risk patients, the number of recurrences could be effectively reduced for the large group of patients responding adequately to the prednisone in vivo sensitivity test.
Journal ArticleDOI
Long-term results of five consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000
Anja Möricke,M Zimmermann,A. Reiter,Günter Henze,André Schrauder,Helmut Gadner,W.-D. Ludwig,J. Ritter,Jochen Harbott,Georg Mann,T. Klingebiel,Felix Zintl,Charlotte M. Niemeyer,Bernhard Kremens,Felix Niggli,Dietrich Niethammer,Karl Welte,Martin Stanulla,E. Odenwald,Hansjörg Riehm,Martin Schrappe +20 more
TL;DR: The major findings derived from these ALL-BFM trials were that preventive cranial radiotherapy could be safely reduced to 12 Gy in T-ALL and high-risk (HR) ALL patients, and eliminated in non- HR non-T-ALL patients, if it was replaced by high-dose and intrathecal (IT) MTX.
Journal ArticleDOI
Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells.
TL;DR: It is described here that constitutively activated NF-κB complexes are found in the vast majority of childhood acute lymphoblastic leukemia (ALL) without any subtype restriction, and strongly suggests a critical role of this factor for leukemia cell survival.
Journal ArticleDOI
Detection of chimeric BCR-ABL genes in acute lymphoblastic leukaemia by the polymerase chain reaction.
J. Maurer,Eckhard Thiel,W.-D. Ludwig,J. W.G. Janssen,C. R. Bartram,B. Heinze,J van Denderen,U. Aydemir,Christa Fonatsch,Jochen Harbott,A. Reiter,Hansjörg Riehm,Dieter Hoelzer +12 more
TL;DR: The polymerase chain reaction was used to look for the BCR-ABL rearrangement in stored samples from a selected group of 314 German ALL patients and transcripts were found in 77 of 179 adults and were restricted to those with B-precursor leukaemias.
Journal ArticleDOI
The Reliability and Specificity of c-kit for the Diagnosis of Acute Myeloid Leukemias and Undifferentiated Leukemias
M C Béné,Michel Bernier,Rene-Olivier Casasnovas,Gian Luigi Castoldi,Walter Knapp,Francesco Lanza,W.-D. Ludwig,Estella Matutes,A. Orfao,Christian Sperling,M. B. Van't Veer +10 more
TL;DR: Findings in ALL and AUL suggest that c-kit identifies a subgroup of cases, which may correspond to leukemias either arising from early prothymocytes and/or early hematopoietic cells, both able to differentiate to the lymphoid and myeloid pathways.