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Waldemar Priebe
Researcher at University of Texas MD Anderson Cancer Center
Publications - 245
Citations - 10108
Waldemar Priebe is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Doxorubicin & Apoptosis. The author has an hindex of 53, co-authored 232 publications receiving 9102 citations. Previous affiliations of Waldemar Priebe include University of Texas System & University of Texas at Austin.
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Journal ArticleDOI
Glioma cancer stem cells induce immunosuppressive macrophages/microglia
Adam Wu,Jun Wei,Ling Yuan Kong,Yongtao Wang,Waldemar Priebe,Wei Qiao,Raymond Sawaya,Amy B. Heimberger +7 more
TL;DR: The gCSCs modulate innate immunity in glioblastoma by inducing immunosuppressive MΦs/microglia, and this capacity can be reversed by inhibiting phosphorylated STAT3.
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2-Deoxy-d-glucose Increases the Efficacy of Adriamycin and Paclitaxel in Human Osteosarcoma and Non-Small Cell Lung Cancers In Vivo
Gregory Maschek,Niramol Savaraj,Waldemar Priebe,Paul G. Braunschweiger,Kara Hamilton,George F. Tidmarsh,Linda R. De Young,Theodore J. Lampidis +7 more
TL;DR: Treatment of tumors with both the glycolytic inhibitor 2-DG and ADR or paclitaxel results in a significant reduction in tumor growth compared with either agent alone, providing a rationale for initiating clinical trials using glyCOlytic inhibitors in combination with chemotherapeutic agents to increase their therapeutic effectiveness.
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A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo.
Arifumi Iwamaru,Slawomir Szymanski,Eiji Iwado,Hiroshi Aoki,Tomohisa Yokoyama,Izabela Fokt,Kenneth R. Hess,Charles A. Conrad,Timothy Madden,Raymond Sawaya,Seiji Kondo,Seiji Kondo,Seiji Kondo,Waldemar Priebe,Yutaka Kondo +14 more
TL;DR: WP1066, a novel inhibitor structurally related to AG490 but significantly more potent and active, is tested against human malignant glioma U87-MG and U373-MG cells in vitro and in vivo and concludes that WP1066 holds promise as a therapeutic agent against malignantgliomas.
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A Novel Small Molecule Inhibitor of Signal Transducers and Activators of Transcription 3 Reverses Immune Tolerance in Malignant Glioma Patients
S. Farzana Hussain,Ling Yuan Kong,Justin T. Jordan,Charles A. Conrad,Timothy Madden,Isabella Fokt,Waldemar Priebe,Amy B. Heimberger +7 more
TL;DR: A novel small molecule inhibitor of STAT3 that can penetrate the central nervous system (CNS) in mice and in physiologically relevant doses in vitro and reverse tolerance in immune cells isolated from glioblastoma multiforme (GBM) patients is described.
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Glioblastoma Cancer-Initiating Cells Inhibit T-Cell Proliferation and Effector Responses by the Signal Transducers and Activators of Transcription 3 Pathway
Jun Wei,Jason Barr,Ling Yuan Kong,Yongtao Wang,Adam Wu,Amit Sharma,Joy Gumin,Verlene Henry,Howard Colman,Waldemar Priebe,Raymond Sawaya,Frederick F. Lang,Amy B. Heimberger +12 more
TL;DR: Findings indicate that cancer-initiating cells contribute to the immune evasion of GBM and that blockade of the STAT3 pathway has therapeutic potential.