Niramol Savaraj

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Treatment of tumors with both the glycolytic inhibitor 2-DG and ADR or paclitaxel results in a significant reduction in tumor growth compared with either agent alone, providing a rationale for initiating clinical trials using glyCOlytic inhibitors in combination with chemotherapeutic agents to increase their therapeutic effectiveness.

TL;DR: The identification of copper transporters as platinum drugtransporters, the structural-functional and mechanistic aspects of these transporators, the mechanisms that regulate their expression, and future research directions that may eventually lead to improved efficacy of platinum-based-based drugs in cancer chemotherapy through modulation of their transporter activities are discussed.

TL;DR: It is concluded that 2-DG seems to be toxic in select tumor cell types growing under normoxia by inhibition of N-linked glycosylation and not by glycolysis, raising the possibility that in certain cases, 2-G could be used as a single agent to selectively kill both the aerobic and hypoxic cells of a solid tumor.

TL;DR: The results suggest that SR2 acquired an additional unique intracellular resistance mechanism to oxaliplatin, and it is shown that the NH2-terminal domain of hCtr1 was involved in transporting all these platinum-based antitumor agents.