Wan-Jung Cheng

TL;DR: The data show that aging is associated with chronic innate immune activation and significant changes in monocyte function, which may have implications for the development of age‐related diseases.

TL;DR: HIV infection induces changes to monocyte phenotype and function in young HIV-positive males that mimic those observed in elderly uninfected individuals, suggesting HIV may accelerate age-related changes tomonocytes.

TL;DR: Quantifying the impact of HIV on immune aging reveals that HIV infection in women confers the equivalent of a 10–14 year increase in the levels of innate immune aging markers, which may contribute to the increased risk of inflammatory age-related diseases in HIV positive women.

TL;DR: It is shown that all monocyte subsets are potentially capable of differentiating into CD163-expressing anti-inflammatory macrophages given appropriate stimuli, and levels of CD163 expression on monocytes may be a potential biomarker reflecting efforts by the immune system to resolve immune activation and inflammation in HIV-infected individuals.

TL;DR: In HIV patients who achieve viral suppression following cART, NK cell activation persists, which suggests that NK cells respond to factors different from those driving T cell activation, but which are associated with inflammation in HIV patients.