W
Wanlu Liu
Researcher at Zhejiang University
Publications - 51
Citations - 2521
Wanlu Liu is an academic researcher from Zhejiang University. The author has contributed to research in topics: Chromatin & DNA methylation. The author has an hindex of 22, co-authored 39 publications receiving 1551 citations. Previous affiliations of Wanlu Liu include University of California, Los Angeles & University of Edinburgh.
Papers
More filters
Journal ArticleDOI
A One Precursor One siRNA Model for Pol IV-Dependent siRNA Biogenesis.
Jixian Zhai,Sylvain Bischof,Haifeng Wang,Suhua Feng,Tzuu-fen Lee,Chong Teng,Xinyuan Chen,Soo Young Park,Linshan Liu,Javier Gallego-Bartolomé,Wanlu Liu,Ian R. Henderson,Blake C. Meyers,Israel Ausin,Steven E. Jacobsen +14 more
TL;DR: In this article, the authors demonstrate that Pol IV-dependent RNAs (P4RNAs) from wild-type Arabidopsis are surprisingly short in length (30 to 40 nt) and mirror 24-nt siRNAs in distribution, abundance, strand bias and 5'-adenine preference.
Journal ArticleDOI
Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory.
William A. Pastor,Di Chen,Wanlu Liu,Rachel Kim,Anna Sahakyan,Anastasia Lukianchikov,Kathrin Plath,Steven E. Jacobsen,Amander T. Clark +8 more
TL;DR: It is discovered that reverting primed hESCs to a hypomethylated naive state or deriving a new hESC line under naive conditions results in the establishment of Stage Specific Embryonic Antigen 4 (SSEA4)-negative h ESC lines with a transcriptional program resembling the human pre-implantation epiblast.
Journal ArticleDOI
Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain
Javier Gallego-Bartolomé,Jason Gardiner,Wanlu Liu,Ashot Papikian,Basudev Ghoshal,Hsuan Yu Kuo,Jenny Miao-Chi Zhao,David J. Segal,Steven E. Jacobsen +8 more
TL;DR: In this article, a fusion between the catalytic domain of the human demethylase TEN-ELEVEN TRANSLOCATION1 (TET1cd) and an artificial zinc finger (ZF) designed to target the FWA promoter can cause highly efficient targeted demethylation, FWA up-regulation, and a heritable late-flowering phenotype.
Journal ArticleDOI
Site-specific manipulation of Arabidopsis loci using CRISPR-Cas9 SunTag systems
TL;DR: It is demonstrated that a dCas9-SunTag system utilizing the transcriptional activator VP64 drives robust and specific activation of several loci, including protein coding genes and transposable elements, in diverse chromatin contexts.
Journal ArticleDOI
A DNA methylation reader complex that enhances gene transcription.
C. Jake Harris,Marion Scheibe,Somsakul Pop Wongpalee,Wanlu Liu,Evan M. Cornett,Robert M. Vaughan,X.Y. Li,Wei Chen,Yan Xue,Zhenhui Zhong,Zhenhui Zhong,Linda Yen,William D. Barshop,Shima Rayatpisheh,Javier Gallego-Bartolomé,Martin Groth,Zonghua Wang,Zonghua Wang,James A. Wohlschlegel,Jiamu Du,Scott B. Rothbart,Falk Butter,Steven E. Jacobsen +22 more
TL;DR: A protein complex that binds methylated DNA can counteract the repressive effects of transposon invasion on neighboring gene expression, thereby counteracting the repressive effect of transPOSon insertion near genes.