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Warren L. Grayson
Researcher at Johns Hopkins University School of Medicine
Publications - 120
Citations - 7345
Warren L. Grayson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Tissue engineering & Stem cell. The author has an hindex of 40, co-authored 106 publications receiving 6237 citations. Previous affiliations of Warren L. Grayson include Florida A&M University – Florida State University College of Engineering & Florida State University.
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Journal ArticleDOI
Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells.
TL;DR: It is demonstrated that oxygen concentrations affected many aspects of stem-cell physiology, including growth and in vitro development, and may be a critical parameter during expansion and differentiation.
Journal ArticleDOI
Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs
TL;DR: Results strongly indicate that oxygen tension is a key parameter that influences the in vitro characteristics of hMSC and their development into tissues.
Journal ArticleDOI
Engineering anatomically shaped human bone grafts
Warren L. Grayson,Mirjam Fröhlich,Keith Yeager,Sarindr Bhumiratana,M. Ete Chan,Christopher Cannizzaro,Leo Q. Wan,X. Sherry Liu,X. Edward Guo,Gordana Vunjak-Novakovic +9 more
TL;DR: It is reported that clinically sized, anatomically shaped, viable human bone grafts can be engineered by using human mesenchymal stem cells (hMSCs) and a “biomimetic” scaffold-bioreactor system to provide patient-specificBone grafts for craniofacial and orthopedic reconstructions.
Journal ArticleDOI
Stromal cells and stem cells in clinical bone regeneration.
Warren L. Grayson,Bruce A. Bunnell,Elizabeth C. Martin,Trivia Frazier,Ben P. Hung,Jeffrey M. Gimble +5 more
TL;DR: Several obstacles blocking the mainstream use of stromal cells to enhance skeletal repair are identified and technological innovations or areas in which novel techniques might be particularly fruitful in continuing to advance the field of skeletal regenerative medicine are highlighted.
Journal ArticleDOI
Tissue engineered bone grafts: biological requirements, tissue culture and clinical relevance.
Mirjam Fröhlich,Warren L. Grayson,Leo Q. Wan,Darja Marolt,Matej Drobnič,Gordana Vunjak-Novakovic +5 more
TL;DR: The biological guidelines for tissue engineering of bone, the bioreactor cultivation of human mesenchymal stem cells on three-dimensional scaffolds, and the need for vascularization and functional integration of bone grafts following implantation are discussed.