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Wataru Shimizu
Researcher at Nippon Medical School
Publications - 764
Citations - 27672
Wataru Shimizu is an academic researcher from Nippon Medical School. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 76, co-authored 671 publications receiving 23910 citations. Previous affiliations of Wataru Shimizu include Mitsubishi Chemical Corporation & Kumamoto University.
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Journal ArticleDOI
Brugada Syndrome: Report of the Second Consensus Conference Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association
Charles Antzelevitch,Pedro Brugada,Martin Borggrefe,Josep Brugada,Ramon Brugada,Domenico Corrado,Ihor Gussak,Herve LeMarec,Koonlawee Nademanee,Andrés Ricardo Pérez Riera,Wataru Shimizu,Eric Schulze-Bahr,H.L. (Hanno) Tan,Arthur A.M. Wilde +13 more
TL;DR: The present report elaborates further on the diagnostic criteria and examines risk stratification schemes and device and pharmacological approaches to therapy on the basis of the available clinical and basic science data.
Journal ArticleDOI
Brugada syndrome: report of the second consensus conference
Charles Antzelevitch,Pedro Brugada,Martin Borggrefe,Josep Brugada,Ramon Brugada,Domenico Corrado,Ihor Gussak,Herve LeMarec,Koonlawee Nademanee,Andrés Ricardo Pérez Riera,Wataru Shimizu,Eric Schulze-Bahr,H.L. (Hanno) Tan,Arthur A.M. Wilde +13 more
TL;DR: The present report elaborates further on the diagnostic criteria and examines risk stratification schemes and device and pharmacological approaches to therapy on the basis of the available clinical and basic science data.
Journal ArticleDOI
An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing.
Jamie D. Kapplinger,David J. Tester,Marielle Alders,Begoña Benito,Myriam Berthet,Josep Brugada,Pedro Brugada,Véronique Fressart,Alejandra Guerchicoff,Carole Harris-Kerr,Shiro Kamakura,Florence Kyndt,Florence Kyndt,Tamara T. Koopmann,Yoshihiro Miyamoto,Ryan Pfeiffer,Guido D. Pollevick,Vincent Probst,Sven Zumhagen,Matteo Vatta,Jeffrey A. Towbin,Wataru Shimizu,Eric Schulze-Bahr,Charles Antzelevitch,Benjamin A. Salisbury,Pascale Guicheney,Arthur A.M. Wilde,Ramon Brugada,Jean-Jacques Schott,Jean-Jacques Schott,Jean-Jacques Schott,Michael J. Ackerman +31 more
TL;DR: Overall, 21% of BrS probands have mutations in SCN5A compared to the 2% to 5% background rate of rare variants reported in healthy control subjects, which may help further distinguish pathogenic mutations from similarly rare but otherwise innocuous ones found in cases.
Journal ArticleDOI
The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart.
Charles Antzelevitch,Wataru Shimizu,Gan-Xin Yan,Serge Sicouri,J Weissenburger,Vladislav V. Nesterenko,Alexander Burashnikov,J. M. Di Diego,Jeffrey E. Saffitz,George Thomas +9 more
TL;DR: A comprehensive characterization of the M cell, its contribution to transmural heterogeneity, and its role in the normal electrical function of the heart, in the inscription of the ECG, and in the development of QT dispersion, T wave alternans, long QT intervals, and cardiac arrhythmias, such as torsades de pointes are provided.
Journal ArticleDOI
Sodium Channel Block With Mexiletine Is Effective in Reducing Dispersion of Repolarization and Preventing Torsade de Pointes in LQT2 and LQT3 Models of the Long-QT Syndrome
TL;DR: The results suggest that although pacing and sodium channel block are very effective in abbreviating the QT interval and TDR in LQT3, these therapeutic approaches may also be valuable in reducing the incidence of arrhythmogenesis in L QT2.