W
Wayne A. Hendrickson
Researcher at Columbia University
Publications - 323
Citations - 40242
Wayne A. Hendrickson is an academic researcher from Columbia University. The author has contributed to research in topics: Protein structure & Receptor. The author has an hindex of 94, co-authored 313 publications receiving 38618 citations. Previous affiliations of Wayne A. Hendrickson include Columbia University Medical Center & Howard Hughes Medical Institute.
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Journal ArticleDOI
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
Peter D. Kwong,Richard T. Wyatt,James E. Robinson,Raymond W. Sweet,Joseph Sodroski,Wayne A. Hendrickson,Wayne A. Hendrickson +6 more
TL;DR: The structure reveals a cavity-laden CD4–gp120 interface, a conserved binding site for the chemokine receptor, evidence for a conformational change upon CD4 binding, the nature of a CD4-induced antibody epitope, and specific mechanisms for immune evasion.
Journal ArticleDOI
The antigenic structure of the HIV gp120 envelope glycoprotein
Richard T. Wyatt,Peter D. Kwong,Elizabeth Desjardins,Raymond W. Sweet,James E. Robinson,Wayne A. Hendrickson,Joseph Sodroski +6 more
TL;DR: The spatial organization of conserved neutralization epitopes on gp120 is described, using epitope maps in conjunction with the X-ray crystal structure of a ternary complex that includes a gp120 core, CD4 and a neutralizing antibody.
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Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK
Xiaotian Zhu,Xun Zhao,William F. Burkholder,Alexander Gragerov,Craig M. Ogata,Max E. Gottesman,Wayne A. Hendrickson +6 more
TL;DR: The crystal structure of a peptide complex with the substrate-binding unit of DnaK has been determined at 2.0 Å resolution, which suggests a model of conformation-dependent substrate binding that features a latch mechanism for maintaining long lifetime complexes.
Journal ArticleDOI
Structural basis of cell-cell adhesion by cadherins.
Lawrence Shapiro,Allison M. Fannon,Peter D. Kwong,Andrew J. Thompson,Mogens S. Lehmann,Gerhard Grübel,Jean-François Legrand,Jean-François Legrand,Jens Als-Nielsen,Jens Als-Nielsen,David R. Colman,Wayne A. Hendrickson +11 more
TL;DR: A linear zipper of molecules that mirrors the linear structure of the intracellular filaments with which cadherins associate may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells.
Journal ArticleDOI
Determination of Macromolecular Structures from Anomalous Diffraction of Synchrotron Radiation
TL;DR: The problem of determining the three-dimensional structure of thousands of atoms is reduced to that of initially solving for a few anomalous scattering centers that can be used as a reference for developing the entire structure.