R
Raymond W. Sweet
Researcher at GlaxoSmithKline
Publications - 13
Citations - 2248
Raymond W. Sweet is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Antigen & Phage display. The author has an hindex of 9, co-authored 13 publications receiving 2177 citations.
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Journal ArticleDOI
The antigenic structure of the HIV gp120 envelope glycoprotein
Richard T. Wyatt,Peter D. Kwong,Elizabeth Desjardins,Raymond W. Sweet,James E. Robinson,Wayne A. Hendrickson,Joseph Sodroski +6 more
TL;DR: The spatial organization of conserved neutralization epitopes on gp120 is described, using epitope maps in conjunction with the X-ray crystal structure of a ternary complex that includes a gp120 core, CD4 and a neutralizing antibody.
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Crystal structure of an HIV-binding recombinant fragment of human CD4.
Seong Eon Ryu,Peter D. Kwong,Alemseged Truneh,Terence G. Porter,James Arthos,Martin Rosenberg,Xiaoping Dai,Nguyen Huu Xuong,Richard Axel,Richard Axel,Raymond W. Sweet,Wayne A. Hendrickson,Wayne A. Hendrickson +12 more
TL;DR: The structure of a soluble fragment of CD4 determined at 2.3 Å resolution reveals that the molecule has two intimately associated immunoglobulin-like domains, implicated in HIV recognition by analysis of mutants and antibody binding.
Journal ArticleDOI
Second antibody modeling assessment (AMA‐II)
Juan Carlos Almagro,Alexey Teplyakov,Jinquan Luo,Raymond W. Sweet,Kodangattil Sreekumar R,Francisco Hernandez-Guzman,Gary L. Gilliland +6 more
TL;DR: An overview of the organization, participants and main results of this second antibody modeling assessment (AMA‐II) is provided and the results are compared with the first antibody assessment published in this journal.
Journal ArticleDOI
Antibody modeling assessment
Juan Carlos Almagro,Mary Pat Beavers,Francisco Hernandez-Guzman,Johannes K. X. Maier,Jodi Shaulsky,Kenneth J. Butenhof,Paul Labute,Nels Thorsteinson,Kenneth Kelly,Alexey Teplyakov,Jinquan Luo,Raymond W. Sweet,Gary L. Gilliland +12 more
TL;DR: A blinded study to assess the state of the art in three‐dimensional structure modeling of the variable region (Fv) of antibodies was conducted, finding good agreement between the models and x‐ray structures.
Journal ArticleDOI
De novo selection of high-affinity antibodies from synthetic fab libraries displayed on phage as pIX fusion proteins.
Lei Shi,John Wheeler,Raymond W. Sweet,Jin Lu,Jinquan Luo,Mark Tornetta,Brian Whitaker,Ramachandra Reddy,Raymond Brittingham,Lina Borozdina,Qiang Chen,Bernard Amegadzie,David M. Knight,Juan Carlos Almagro,Ping Tsui +14 more
TL;DR: The results demonstrate the feasibility of displaying complex Fab libraries as pIX fusion proteins for antibody discovery and optimization and lay the foundation for studies on the structure-function relationships of antibodies.