Wei Liu

TL;DR: Improved understanding of the molecular mechanisms of ER stress in heart disease will help to investigate more potential targets for new therapeutic interventions and drug discovery.

TL;DR: It is discovered that the Pak1 activator FTY720, a sphingosine-like analog, was able to prevent pressure overload-induced hypertrophy in wild-type mice without compromising their cardiac functions, suggesting that it may be a potential therapeutic target for the treatment of cardiachypertrophy and heart failure.

TL;DR: Results reveal an important function of ERK5 in cardiac hypertrophic remodeling and cardiomyocyte survival that is likely to be mediated via the regulation of MEF2 activity.

TL;DR: It is shown that in the absence of IL-13Rα2,IL-13-induced pulmonary inflammation, mucus metaplasia, subepithelial fibrosis, and airway remodeling are significantly augmented and an enhanced inflammatory response was observed in an OVA-induced phenotype.

TL;DR: This study provides the first direct evidence of the behavior of plasma sphingolipids following transient cardiac ischemia with dramatic and early increases in LCSB in humans and demonstrates that S1P, SPH, and FTY720 have protective effects against hypoxic/ischemic cell injury, likely a Pak1/Akt1 signaling cascade and nitric oxide release.