Z
Zhou Zhu
Researcher at Yale University
Publications - 129
Citations - 19843
Zhou Zhu is an academic researcher from Yale University. The author has contributed to research in topics: Inflammation & Interleukin 13. The author has an hindex of 53, co-authored 123 publications receiving 18621 citations. Previous affiliations of Zhou Zhu include University of Alabama at Birmingham & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Heon Park,Zhaoxia Li,Xuexian O. Yang,Seon Hee Chang,Roza Nurieva,Yi Hong Wang,Ying Wang,Leroy Hood,Zhou Zhu,Qiang Tian,Chen Dong +10 more
TL;DR: In vivo, antibody to IL- 17 inhibited chemokine expression in the brain during experimental autoimmune encephalomyelitis, whereas overexpression of IL-17 in lung epithelium caused Chemokine production and leukocyte infiltration, indicating a unique T helper lineage that regulates tissue inflammation.
Journal ArticleDOI
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
Zhou Zhu,Robert J. Homer,Robert J. Homer,Zhonde Wang,Qingsheng Chen,Gregory P. Geba,Gregory P. Geba,Jingming Wang,Yong Zhang,Jack A. Elias +9 more
TL;DR: The targeted pulmonary expression of IL-13 causes a mononuclear and eosinophilic inflammatory response, mucus cell metaplasia, airway fibrosis, eotaxin production, airways obstruction, and nonspecific AHR in transgene-positive animals.
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Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
Douglas A. Kuperman,Xiaozhu Huang,Laura L. Koth,Grace H.-F. Chang,Gregory Dolganov,Zhou Zhu,Jack A. Elias,Dean Sheppard,David J. Erle +8 more
TL;DR: The results demonstrate the importance of direct effects of IL-13 on epithelial cells in causing two central features of asthma, including airway hyperreactivity and mucus overproduction.
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Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1
Chun Geun Lee,Robert J. Homer,Zhou Zhu,Sophie Lanone,Xiaoman Wang,Victor Koteliansky,J. Michael Shipley,Philip Gotwals,Paul W. Noble,Qingsheng Chen,Robert M. Senior,Jack A. Elias +11 more
TL;DR: It is demonstrated that IL-13 is a potent stimulator and activator of TGF-β1 in vivo and that this activation is mediated by a plasmin/serine protease- and MMP-9–dependent and CD44-independent mechanism and that the fibrogenic effects of IL- 13 are mediated, in great extent, by this T GF-β pathway.
Journal ArticleDOI
Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation
Zhou Zhu,Tao Zheng,Robert J. Homer,Yoon Keun Kim,Ning Yuan Chen,Lauren Cohn,Qutayba Hamid,Jack A. Elias +7 more
TL;DR: It is shown that acidic mammalian chitinase (AMCase) is induced via a T helper-2 (Th2)–specific, interleukin-13 (IL-13)–mediated pathway in epithelial cells and macrophages in an aeroallergen asthma model and expressed in exaggerated quantities in human asthma.