Wei Wu

TL;DR: Interestingly, mutations in EZH2 and certain BAF complex components have roles in both neurodevelopmental disorders and cancer, and overlapping point mutations are suggesting functionally important residues and domains.

TL;DR: This work develops a high-throughput ELISA-based binding assay and provides evidence that 95% (>18,000) of Dscam isoforms exhibit striking isoform-specific homophilic binding, thereby allowing neuronal processes to distinguish between self and nonself.

TL;DR: It is shown that the immunoglobulin superfamily member Dscam2 restricts the connections formed by L1 lamina neurons to columns in the Drosophila visual system, and it is proposed that D scam2 is a tiling receptor for L1 neurons, which mediate repulsion between neurites of L1 cells in neighbouring columns.

TL;DR: Structural, genetic, and biochemical studies demonstrate that, in addition to variable domain "matching," intramolecular interactions between constant domains promote homophilic binding.

TL;DR: The kinetics of neuron-specific BAF complex assembly in the formation of induced neurons from mouse embryonic stem cells, human fibroblasts, and normal mouse neural differentiation are defined and it is found that switching of chromatin remodeling mechanisms is highly correlated with a broad switch in the use of neurogenic transcription factors.