C
Claudio P. Albuquerque
Researcher at Ludwig Institute for Cancer Research
Publications - 26
Citations - 2806
Claudio P. Albuquerque is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Phosphorylation & SUMO protein. The author has an hindex of 18, co-authored 26 publications receiving 2456 citations. Previous affiliations of Claudio P. Albuquerque include University of California, San Diego.
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Journal ArticleDOI
A Multidimensional Chromatography Technology for In-depth Phosphoproteome Analysis
Claudio P. Albuquerque,Claudio P. Albuquerque,Marcus B. Smolka,Samuel H. Payne,Vineet Bafna,Jimmy K. Eng,Huilin Zhou,Huilin Zhou +7 more
TL;DR: A multidimensional chromatography technology, combining IMAC, hydrophilic interaction chromatography, and reverse phase LC, for phosphopeptide purification and fractionation is developed, suited for in-depth phosphoproteome studies.
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Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.
TL;DR: Qualitative phosphoproteomics was used to identify in vivo kinase substrates of the yeast DNA damage checkpoint kinases Mec1, Tel1, and Rad53 (orthologs of human ATR, ATM, and CHK2, respectively), suggesting that a wide range of cellular processes is likely regulated by these kinases.
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ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
Shuo-Chien Ling,Claudio P. Albuquerque,Joo Seok Han,Clotilde Lagier-Tourenne,Seiya Tokunaga,Huilin Zhou,Don W. Cleveland +6 more
TL;DR: In this paper, Tandem-affinity purification and quantitative mass spectrometry were used to identify TDP-43 complexes not only with heterogeneous nuclear ribonucleoproteins family proteins, as expected, but also with components of Drosha microprocessor complexes, consistent with roles for TDP43 in both mRNA processing and microRNA biogenesis.
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ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.
Shuying Sun,Shuo-Chien Ling,Shuo-Chien Ling,Jinsong Qiu,Claudio P. Albuquerque,Yu Zhou,Seiya Tokunaga,Hairi Li,Haiyan Qiu,Anh Bui,Gene W. Yeo,Eric J. Huang,Kevin Eggan,Huilin Zhou,Xiang-Dong Fu,Clotilde Lagier-Tourenne,Don W. Cleveland +16 more
TL;DR: These studies establish potentially converging disease mechanisms in ALS and spinal muscular atrophy, with ALS-causative mutants acquiring properties representing both gain and loss of function, including reduced RNA processing mediated by U1-snRNP.
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Identification of H3K4me1-associated proteins at mammalian enhancers.
Andrea Local,Hui Huang,Hui Huang,Claudio P. Albuquerque,Namit Singh,Ah Young Lee,Wei Wang,Chaochen Wang,Judy E. Hsia,Andrew K. Shiau,Kai Ge,Kevin D. Corbett,Kevin D. Corbett,Dong Wang,Huilin Zhou,Huilin Zhou,Bing Ren,Bing Ren,Bing Ren +18 more
TL;DR: It is demonstrated that H3K4me1 augments association of the chromatin-remodeling complex BAF to enhancers in vivo and that, in vitro, H 3K4 me1-marked nucleosomes are more efficiently remodeled by the BAF complex.