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Weiwei Xu
Researcher at Tulane University
Publications - 17
Citations - 531
Weiwei Xu is an academic researcher from Tulane University. The author has contributed to research in topics: Androgen receptor & Dihydrotestosterone. The author has an hindex of 8, co-authored 12 publications receiving 389 citations. Previous affiliations of Weiwei Xu include Yale University & Sichuan Agricultural University.
Papers
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Journal ArticleDOI
The role of androgens in metabolism, obesity and diabetes in males and females
TL;DR: There is a bidirectional modulation of glucose homeostasis by androgens in males and females that is analyzed in this review.
Journal ArticleDOI
Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male
Guadalupe Navarro,Weiwei Xu,David A. Jacobson,Barton Wicksteed,Camille Allard,Guanyi Zhang,Karel De Gendt,Sung Hoon Kim,Hongju Wu,Haitao Zhang,Guido Verhoeven,John A. Katzenellenbogen,Franck Mauvais-Jarvis,Franck Mauvais-Jarvis +13 more
TL;DR: This study identifies AR as a novel receptor that enhances β cell function, a finding with implications for the prevention of T2D in aging men.
Journal ArticleDOI
GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner.
Yanqing Zhang,Keshab R. Parajuli,Genevieve E. Fava,Rajesh Gupta,Weiwei Xu,Lauren U. Nguyen,Anadil F. Zakaria,Vivian Fonseca,Hongjun Wang,Franck Mauvais-Jarvis,Kyle W. Sloop,Hongju Wu +11 more
TL;DR: It is demonstrated that GLP-1 (via GLp-1R in α-cells) plays a bidirectional role, either stimulatory or inhibitory, in glucagon secretion depending on glucose levels.
Journal ArticleDOI
Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes
Guadalupe Navarro,Camille Allard,Jamie Morford,Weiwei Xu,Suhuan Liu,Adrien J.R. Molinas,Sierra M. Butcher,Nicholas H. F. Fine,Manuel Blandino-Rosano,Venkata N. Sure,Sangho Yu,Rui Zhang,Heike Münzberg,David A. Jacobson,Prasad V. G. Katakam,David J. Hodson,David J. Hodson,Ernesto Bernal-Mizrachi,Andrea Zsombok,Franck Mauvais-Jarvis +19 more
TL;DR: It is suggested that excess androgen predisposes female mice to T2D following AR activation in neurons, producing peripheral insulin resistance, and in pancreatic β cells, promoting insulin hypersecretion, oxidative injury, and secondary β cell failure.
Journal ArticleDOI
Loss of Nuclear and Membrane Estrogen Receptor-α Differentially Impairs Insulin Secretion and Action in Male and Female Mice.
Camille Allard,Jamie Morford,Beibei Xu,Benjamin Salwen,Weiwei Xu,Lucie Delphine Desmoulins,Andrea Zsombok,Jason K. Kim,Ellis R. Levin,Ellis R. Levin,Franck Mauvais-Jarvis +10 more
TL;DR: Lack of nuclear ERα alters the central control of insulin sensitivity in females and predominantly impairs the central regulation of insulin secretion in males, and nuclear ER α signaling is predominant in maintaining glucose homeostasis in mice of both sexes.