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Franck Mauvais-Jarvis

Researcher at Tulane University

Publications -  166
Citations -  13934

Franck Mauvais-Jarvis is an academic researcher from Tulane University. The author has contributed to research in topics: Diabetes mellitus & Insulin. The author has an hindex of 50, co-authored 144 publications receiving 11254 citations. Previous affiliations of Franck Mauvais-Jarvis include Centre national de la recherche scientifique & University of Paris.

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Endocrine Regulation of Energy Metabolism by the Skeleton

TL;DR: It is shown that mice lacking the protein tyrosine phosphatase OST-PTP are hypoglycemic and are protected from obesity and glucose intolerance because of an increase in beta-cell proliferation, insulin secretion, and insulin sensitivity, and in vivo osteocalcin can improve glucose tolerance.
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The role of estrogens in control of energy balance and glucose homeostasis.

TL;DR: The literature in both rodents and humans on the role of estrogens and their receptors in the control of energy homeostasis and glucose metabolism in health and metabolic diseases is reviewed.
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Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

TL;DR: To determine the importance of glucose uptake into muscle for glucose homeostasis, disruption of GLUT4 selectively in mouse muscles resulted in a profound reduction in basal glucose transport and near-absence of stimulation by insulin or contraction.
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Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice

TL;DR: It is demonstrated that estradiol, acting, at least in part, through ERalpha, protects beta-cells from oxidative injury and prevents diabetes in mice of both genders.