Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male
Guadalupe Navarro,Weiwei Xu,David A. Jacobson,Barton Wicksteed,Camille Allard,Guanyi Zhang,Karel De Gendt,Sung Hoon Kim,Hongju Wu,Haitao Zhang,Guido Verhoeven,John A. Katzenellenbogen,Franck Mauvais-Jarvis,Franck Mauvais-Jarvis +13 more
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TLDR
This study identifies AR as a novel receptor that enhances β cell function, a finding with implications for the prevention of T2D in aging men.About:
This article is published in Cell Metabolism.The article was published on 2016-05-10 and is currently open access. It has received 120 citations till now. The article focuses on the topics: Dihydrotestosterone & Androgen receptor.read more
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Gender differences in glucose homeostasis and diabetes
TL;DR: This review discusses the most fundamental gender differences in glucose homeostasis and diabetes, including the prevalence of impaired fasting glucose and impaired glucose tolerance, the prevalence and incidence of type 2 and type 1 diabetes, and the sex-specific effects of testosterone and estrogen deficiency and excess.
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Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies.
TL;DR: Androgen excess plays a prominent role in the development of metabolic disturbances associated withPCOS, with a discernible impact on key peripheral metabolic tissues and the brain, contributing to the constellation of metabolic complications of PCOS, from obesity to insulin resistance.
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A Guide for the Design of Pre-clinical Studies on Sex Differences in Metabolism
TL;DR: Experimental design and interpretation in studies addressing the mechanisms of sex differences in metabolic homeostasis and disease, using animal models and cells are discussed.
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Role of Sex Steroids in β Cell Function, Growth, and Survival
TL;DR: A perspective on the physiological roles of estrogen, androgens, and P4 via their receptors in pancreatic β cells in the gender-specific tuning of insulin secretion is presented.
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Sex differences underlying pancreatic islet biology and its dysfunction
TL;DR: Important sex differences exist in islet cell function and susceptibility to failure that represent sex-related biological factors that can be harnessed for gender-based prevention of and therapy for diabetes.
References
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The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
TL;DR: Clinical trials with the incretin mimetic exenatide and liraglutide show reductions in fasting and postprandial glucose concentrations, and haemoglobin A1c (HbA1c) associated with weight loss, but long-term clinical studies are needed to determine the benefits of targeting the inc retin axis for the treatment of type 2 diabetes.
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In vivo amplification of the androgen receptor gene and progression of human prostate cancer.
Tapio Visakorpi,E. Hyytinen,Pasi A. Koivisto,Minna Tanner,Riitta Keinänen,C. Palmberg,Aarno Palotie,Teuvo L.J. Tammela,Jorma Isola,Olli-P. Kallioniemi +9 more
TL;DR: This work has identified a similar molecular mechanism in vivo for endocrine treatment failure in human prostate cancer which involves amplification of the androgen receptor (AR) gene.
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Cloning of human androgen receptor complementary DNA and localization to the X chromosome.
Dennis B. Lubahn,David R. Joseph,Patrick Sullivan,Huntington F. Willard,Frank S. French,Elizabeth M. Wilson +5 more
TL;DR: The deduced amino acid sequence of AR within the DNA-binding domain has highest sequence identity with the progesterone receptor.
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Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.
Rüdiger Göke,Hans-Christoph Fehmann,T. Linn,Harald Schmidt,Michael Krause,J. Eng,Burkhard Göke +6 more
TL;DR: Exendin-4 is an agonist and exendin-(9-39)-amide is a specific GLP-1 receptor antagonist, and both peptides stimulated the proinsulin gene expression at the level of transcription and reduced the effects of cAMP.
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Molecular Cloning of Human and Rat Complementary DNA Encoding Androgen Receptors
TL;DR: Complementary DNAs (cDNAs) encoding androgen receptors were obtained from human testis and rat ventral prostate cDNA libraries and indicated the presence of a cysteine-rich DNA-binding domain that is highly conserved in all steroid receptors.