Wen Tan

TL;DR: Recent advances in in vitro and invivo research on the anti-cancer effects and related mechanisms of some promising natural products isolated from Chinese medicinal herbs are summarized.

TL;DR: Herb pairs have played, and may continue to play a key role in full investigation of general herb compatibility for their indispensable position in TCM, and much more research is needed for the standardization, safety evaluation, and mechanism exploration of herb pairs.

TL;DR: Berberine hydrochloride is likely to become a natural component of the nanoparticulate delivery systems used for cancer therapy, and the known mechanisms of berberine Hydrochloride, such as decreased multidrug resistance and enhanced sensitivity of chemotherapeutic drugs, could also provide new insights into cancer cell metabolism and nanopartICulate delivery preparation.

TL;DR: To fully exploit the potential of PCHM in cancer therapy, more attentions are advocated to be focused on their safety evaluation and mechanism exploration.

TL;DR: The results have advanced the current understandings of the anti-cancer mechanisms of GADM and induced DNA fragmentation and cleavage of PARP which are the characteristics of apoptosis and decreased the mitochondrial membrane potential in MCF-7 cells.