Journal ArticleDOI
Fighting fire with fire: poisonous Chinese herbal medicine for cancer therapy.
TLDR
To fully exploit the potential of PCHM in cancer therapy, more attentions are advocated to be focused on their safety evaluation and mechanism exploration.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2012-03-06. It has received 147 citations till now.read more
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The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer
TL;DR: Current evidence for using TCM as adjuvant cancer treatment in different stages of cancer lesions is summarized to contribute to an understanding of Chinese herbal medicines as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer.
Journal ArticleDOI
Polymeric mixed micelles as nanomedicines: Achievements and perspectives
Maximiliano Cagel,Fiorella Carla Tesan,Ezequiel Bernabeu,María J. Salgueiro,Marcela Zubillaga,Marcela A. Moretton,Diego A. Chiappetta,Diego A. Chiappetta +7 more
TL;DR: An overview on the current state of the art of several mixed micellar formulations as nanocarriers for drugs and imaging probes, evaluating their ongoing status (preclinical or clinical stage), with special emphasis on type of copolymers, physicochemical properties, in vivo progress achieved so far and toxicity profiles is given.
Journal ArticleDOI
Compatibility art of traditional Chinese medicine: From the perspective of herb pairs
TL;DR: Herb pairs have played, and may continue to play a key role in full investigation of general herb compatibility for their indispensable position in TCM, and much more research is needed for the standardization, safety evaluation, and mechanism exploration of herb pairs.
Journal ArticleDOI
Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine.
Hua Luo,Chi Teng Vong,Hanbin Chen,Yan Gao,Peng Lyu,Ling Qiu,Mingming Zhao,Qiao Liu,Zehua Cheng,Jian Zou,Peifen Yao,Caifang Gao,Jinchao Wei,Carolina Oi Lam Ung,Shengpeng Wang,Zhangfeng Zhong,Yitao Wang +16 more
TL;DR: The present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshin one in view of their potentials in cancer therapy.
Journal ArticleDOI
Skin wound healing and phytomedicine: a review.
TL;DR: The common beneficial medicinal plants in the management of skin wounds are reviewed with an attempt to explain their mechanisms.
References
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Journal ArticleDOI
Natural Products as Sources of New Drugs over the Last 25 Years
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003 and is able to identify only one de novo combinatorial compound approved as a drug in this 25 plus year time frame.
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Delivering nanomedicine to solid tumors
TL;DR: In this paper, the authors review the barriers to the delivery of cancer therapeutics and summarize strategies that have been developed to overcome these barriers and discuss design considerations for optimizing the nanoparticles to tumors.
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To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
TL;DR: Delivery of conventional chemotherapeutic anti-cancer drugs is mainly discussed and exploitation and the understanding of these characteristics to design new drug delivery systems targeting the tumor are focused on.
Journal ArticleDOI
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) : I. As2O3 exerts dose-dependent dual effects on APL cells
Guo-Qiang Chen,Xue-Geng Shi,Wei Tang,Shu-Min Xiong,Jun Zhu,Xun Cai,Ze-Guang Han,Jian-Hua Ni,Gui-Ying Shi,Pei-Ming Jia,Meng-Min Liu,Kai-Li He,Chao Niu,Jun Ma,Peng Zhang,Ting-Dong Zhang,Pascale Paul,Tomoki Naoe,Kunio Kitamura,Wilson H. Miller,Samuel Waxman,Zhen-Yi Wang,Sai-Juan Chen,Zhu Chen +23 more
TL;DR: Combination of induction of apoptosis and partial differention could be the main cellular mechanisms of As2O3 in the treatment of APL, and PML-RAR alpha could play an important role in determining the specific effects of As 2O3 on APL cells.
Journal ArticleDOI
Targeting nanoparticles to cancer.
TL;DR: There is still a room for optimisation in the area of the nanoparticle kinetics such as improving their plasma circulation and tumour bioavailability and understanding the effect of targeting ligands on their efficiency to treat cancer.