W
Wenbin Deng
Researcher at Sun Yat-sen University
Publications - 129
Citations - 4958
Wenbin Deng is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Induced pluripotent stem cell & Cellular differentiation. The author has an hindex of 35, co-authored 115 publications receiving 4217 citations. Previous affiliations of Wenbin Deng include Shriners Hospitals for Children & University of California, Davis.
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Journal ArticleDOI
Glutamate Receptor-Mediated Oligodendrocyte Toxicity in Periventricular Leukomalacia: A Protective Role for Topiramate
Pamela L. Follett,Wenbin Deng,Weimin Dai,Delia M. Talos,Leon J. Massillon,Paul A. Rosenberg,Joseph J. Volpe,Frances E. Jensen +7 more
TL;DR: Results suggest that AMPA–kainate receptor blockade may have potential for translation as a therapeutic strategy for periventricular leukomalacia and that the mechanism of protective efficacy of topiramate is caused at least in part by attenuation of excitotoxic injury to premyelinating oligodendrocytes in developing white matter.
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Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers
TL;DR: This review highlights recent advances in the development of SCMs for cancer therapy and introduces the latest biophysical techniques, such as electron paramagnetic resonance (EPR) spectroscopy and fluorescence resonance energy transfer (FRET), for the characterization of the interactions between SCMs and blood proteins.
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Prospects for Minocycline Neuroprotection
TL;DR: The objective is to critically review the biological basis and translational potential of this action of minocycline on the nervous system.
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Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis.
Kanako Morohaku,Susanne H. Pelton,Daniel J. Daugherty,W. Ronald Butler,Wenbin Deng,Vimal Selvaraj +5 more
TL;DR: The results show that TSPO function is not essential for steroid hormone biosynthesis and challenge the prevailing dogma that claims an essential role for T SPO in steroid hormone synthesis and force reexamination of functional interpretations made for this protein.
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Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors.
TL;DR: Aberrantly enhanced activation of Ca2+-permeable AMPA/kainate receptors may be a major mechanism in acute and repeated hypoxic–ischemic injury to OPCs in disorders of developing cerebral white matter, such as PVL.