V
Vimal Selvaraj
Researcher at Cornell University
Publications - 71
Citations - 2535
Vimal Selvaraj is an academic researcher from Cornell University. The author has contributed to research in topics: Translocator protein & Induced pluripotent stem cell. The author has an hindex of 29, co-authored 63 publications receiving 2173 citations. Previous affiliations of Vimal Selvaraj include Ithaca College & University of California, Davis.
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Journal ArticleDOI
Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis.
Kanako Morohaku,Susanne H. Pelton,Daniel J. Daugherty,W. Ronald Butler,Wenbin Deng,Vimal Selvaraj +5 more
TL;DR: The results show that TSPO function is not essential for steroid hormone biosynthesis and challenge the prevailing dogma that claims an essential role for T SPO in steroid hormone synthesis and force reexamination of functional interpretations made for this protein.
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Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis.
Lan N. Tu,Kanako Morohaku,Pulak R. Manna,Susanne H. Pelton,W. Ronald Butler,Douglas M. Stocco,Vimal Selvaraj +6 more
TL;DR: In an attempt to correlate the in vivo findings to previously used in vitro models, it is determined that siRNA knockdown or the absence of TSPO in different mouse and human steroidogenic cell lines had no effect on steroidogenesis.
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A TSPO ligand is protective in a mouse model of multiple sclerosis
Daniel J. Daugherty,Vimal Selvaraj,Vimal Selvaraj,Olga Chechneva,Xiao Bo Liu,David E Pleasure,Wenbin Deng,Wenbin Deng +7 more
TL;DR: The results suggest that a TSPO ligand, e.g. etifoxine, could be a potential new therapeutic option for MS with benefits that could be comparable to the administration of systemic steroids but potentially avoiding the detrimental side effects of long‐term direct use of steroids.
Journal ArticleDOI
The changing landscape in translocator protein (TSPO) function.
Vimal Selvaraj,Douglas M. Stocco +1 more
TL;DR: A review summarizes the history of TSPO, key elements of the debate, and functional experiments that have changed understanding and examines how this fundamental change impacts the understanding of T SPO and affects the future of TspO as a therapeutic and diagnostic target.
Journal ArticleDOI
Switching cell fate: the remarkable rise of induced pluripotent stem cells and lineage reprogramming technologies
TL;DR: Landmark developments in cell reprogramming, current knowledge, and technological developments now on the horizon with significant promise for biomedical applications are reviewed.