K
Kanako Morohaku
Researcher at Shinshu University
Publications - 16
Citations - 762
Kanako Morohaku is an academic researcher from Shinshu University. The author has contributed to research in topics: Translocator protein & Oogenesis. The author has an hindex of 10, co-authored 15 publications receiving 666 citations. Previous affiliations of Kanako Morohaku include Cornell University & Tohoku University.
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Journal ArticleDOI
Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis.
Kanako Morohaku,Susanne H. Pelton,Daniel J. Daugherty,W. Ronald Butler,Wenbin Deng,Vimal Selvaraj +5 more
TL;DR: The results show that TSPO function is not essential for steroid hormone biosynthesis and challenge the prevailing dogma that claims an essential role for T SPO in steroid hormone synthesis and force reexamination of functional interpretations made for this protein.
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Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis.
Lan N. Tu,Kanako Morohaku,Pulak R. Manna,Susanne H. Pelton,W. Ronald Butler,Douglas M. Stocco,Vimal Selvaraj +6 more
TL;DR: In an attempt to correlate the in vivo findings to previously used in vitro models, it is determined that siRNA knockdown or the absence of TSPO in different mouse and human steroidogenic cell lines had no effect on steroidogenesis.
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Complete in vitro generation of fertile oocytes from mouse primordial germ cells
Kanako Morohaku,Ren Tanimoto,Keisuke Sasaki,Ryouka Kawahara-Miki,Tomohiro Kono,Katsuhiko Hayashi,Yuji Hirao,Yayoi Obata +7 more
TL;DR: The first reconstitution, to the authors' knowledge, of the entire process of mammalian oogenesis in vitro from primordial germ cells is demonstrated, using an estrogen-receptor antagonist that promotes normal follicle formation, which in turn is crucial for supporting oocyte growth.
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A brief history of the search for the protein(s) involved in the acute regulation of steroidogenesis
TL;DR: In this review, the process of regulating steroidogenesis is briefly described, the characteristics of the candidate proteins and the data supporting their candidacies summarized, and some recent findings that propose a serious challenge for the role of TSPO in this process are discussed.
Journal ArticleDOI
Mitochondrial translocator protein (TSPO) function is not essential for heme biosynthesis
Amy H. Zhao,Lan N. Tu,Chinatsu Mukai,Madhu P. Sirivelu,Viju V. Pillai,Kanako Morohaku,Roy Cohen,Vimal Selvaraj +7 more
TL;DR: It is demonstrated that TSPO deficiency does not adversely affect erythropoiesis, heme biosynthesis, bioconversion of ALA to PPIX, and porphyrin-mediated phototoxic cell death, and mitochondrial bioenergetic homeostasis.