Wenchao Wang

TL;DR: A transgenic zebrafish model of neuroblastoma is generated in which MYCN-induced tumors arise from a subpopulation of neuroblasts that migrate into the adrenal medulla analog following organogenesis, and coexpression of activated ALK with MYCN in this model triples the disease penetrance and markedly accelerates tumor onset.

TL;DR: Combined treatment with the ATP-competitive mTOR inhibitor Torin2 overcame the resistance of ALK(F1174L)/MYCN tumors to crizotinib and suggested a strategy for improving targeted therapy for ALK-positive neuroblastoma.

TL;DR: It is demonstrated that H3K27me and PRC2 each contribute to epigenetically transmitting the memory of repression across generations and during development.

TL;DR: It is proposed that all four MES proteins participate in X-chromosome silencing, and that the role of MES-4 is to exclude repressors from the autosomes, thus enabling efficient repression of the Xs.

TL;DR: It is shown that, when grown at high temperature, a majority of synMuv B mutants irreversibly arrest at the L1 stage, revealing that arrest is caused by somatic cells possessing a germline-like chromatin state.