W
Wenda Gao
Researcher at Beth Israel Deaconess Medical Center
Publications - 99
Citations - 17909
Wenda Gao is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Interleukin 21 & FOXP3. The author has an hindex of 41, co-authored 89 publications receiving 16636 citations. Previous affiliations of Wenda Gao include Tufts University & Third Military Medical University.
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Journal ArticleDOI
In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche
Joji Fujisaki,Juwell W. Wu,Juwell W. Wu,Alicia L. Carlson,Lev Silberstein,Prabhakar Putheti,Rafael A. Larocca,Wenda Gao,Toshiki I. Saito,Toshiki I. Saito,Cristina Lo Celso,Hitoshi Tsuyuzaki,Tatsuyuki Sato,Daniel Côté,Megan Sykes,Megan Sykes,Terry B. Strom,David T. Scadden,Charles P. Lin +18 more
TL;DR: In this article, the bone marrow haematopoietic stem cell (HSC) niche is identified as an immune privileged site, where regulatory T cells are necessary for allo-HSPC persistence.
Journal ArticleDOI
OX40 costimulation turns off Foxp3+ Tregs.
Minh Diem Vu,Xiang Xiao,Wenda Gao,Nicolas Degauque,Ming Chen,Alexander Kroemer,Nigel Killeen,Naoto Ishii,Xian Chang Li +8 more
TL;DR: OX40 was dispensable for the genesis and suppressor functions of naturally arising CD4(+)Foxp3(+) Tregs, but stimulating OX40 on the Foxp3 (+) T Regs abrogated their ability to suppress T effector cell proliferation, IFN-gamma production, and T effectors allograft rejection.
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CD39 and control of cellular immune responses
TL;DR: The data indicate that CD39, together with CD73, efficiently distinguishes T regulatory cells (Treg) from other resting or activated T cells in mice (and humans) and serves as an integral component of the suppressive machinery of Treg, acting, at least in part, through the modulation of pericellular levels of adenosine.
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Contrasting Effects of Cyclosporine and Rapamycin in De Novo Generation of Alloantigen-Specific Regulatory T Cells
TL;DR: It is shown, using reporter mice for Treg marker Foxp3, that RPM promotes de novo conversion of alloantigen‐specific Treg cells, whereas CsA completely inhibits this process, favor the use of RPM in shifting the balance of aggressive to protective type alloimmunity.