T
Terry B. Strom
Researcher at Harvard University
Publications - 137
Citations - 18370
Terry B. Strom is an academic researcher from Harvard University. The author has contributed to research in topics: Transplantation & T cell. The author has an hindex of 43, co-authored 137 publications receiving 17416 citations. Previous affiliations of Terry B. Strom include Brigham and Women's Hospital & Joslin Diabetes Center.
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Journal ArticleDOI
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Estelle Bettelli,Yijun Carrier,Wenda Gao,Thomas Korn,Terry B. Strom,Mohamed Oukka,Howard L. Weiner,Vijay K. Kuchroo +7 more
TL;DR: It is shown that IL-6, an acute phase protein induced during inflammation, completely inhibits the generation of Foxp3+ Treg cells induced by TGF-β, and the data demonstrate a dichotomy in thegeneration of pathogenic (TH17) T cells that induce autoimmunity and regulatory (Foxp3+) T Cells that inhibit autoimmune tissue injury.
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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
Chen Zhu,Ana C. Anderson,Anna Schubart,Huabao Xiong,Jaime Imitola,Samia J. Khoury,Xin Xiao Zheng,Terry B. Strom,Vijay K. Kuchroo +8 more
TL;DR: The data suggest that the Tim-3–galectin-9 pathway may have evolved to ensure effective termination of effector TH1 cells.
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IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells
Valerie Dardalhon,Amit Awasthi,Hyoung-Joon Kwon,George Galileos,Wenda Gao,Raymond A. Sobel,Meike Mitsdoerffer,Terry B. Strom,Wassim Elyaman,I-Cheng Ho,Samia J. Khoury,Mohamed Oukka,Vijay K. Kuchroo +12 more
TL;DR: The authors showed that IL-4 blocked the generation of TGF-beta-induced Foxp3(+) T(reg) cells and instead induced a population of T helper cells that produced IL-9 and IL-10.
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Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
Thomas Korn,Jayagopala Reddy,Wenda Gao,Estelle Bettelli,Amit Awasthi,Troels R. Petersen,B Thomas Bäckström,Raymond A. Sobel,Raymond A. Sobel,Kai W. Wucherpfennig,Terry B. Strom,Mohamed Oukka,Vijay K. Kuchroo +12 more
TL;DR: The data suggest that in order for CD4+Foxp3+ T-reg to effectively control autoimmune reactions in the target organ, it may also be necessary to control tissue inflammation.
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Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.
TL;DR: It is shown that the induction of T cell anergy in vivo is due to an abortive T cell response that requires recognition of B7 molecules, since blocking B7 maintains T cells in an unactivated but functionally competent state.